Project Grant R00HL169733
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a Project Grant of $805,921 on September 10, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research extending through June 30, 2030. This award funds integrated genetic and multi-omic research aimed at deciphering respiratory disease mechanisms, specifically focusing on Chronic Obstructive Pulmonary Disease (COPD) and asthma across diverse...
- Federal Grant Award Summary Brigham & Women's Hospital Inc., through the Department of Faulkner Pathology, received a $249,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective March 10, 2026 through February 28, 2029, funds research investigating the mechanistic links between clonal hematopoiesis of indeterminate potential (CHIP) and coronary artery disease (CAD) using...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Massachusetts Medical School a $762,969 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective September 1, 2025, through June 30, 2030, to investigate the role of perivascular adipose tissue (PVAT) in atherosclerotic cardiovascular disease (ASCVD). The research addresses the observation that certain arteries, particularly the left internal mammary artery (LIMA),...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a Project Grant totaling $117,525 on July 7, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The three-year project, extending through June 30, 2028, supports fundamental research investigating cellular adaptation mechanisms in response to one-carbon (1C) metabolism perturbation, with particular focus on erythroid cell responses to folate deprivation. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,119,410 Project Grant to Tufts University School of Medicine on September 17, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multiethnic and multi-omics analysis of longitudinal changes in DNA methylation (LC-DNAM) and cardiovascular health. The research initiative, extending through July 31, 2029, investigates how DNA methylation changes across time relate to...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $773,479 Project Grant to Harvard College's Office for Sponsored Programs on August 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research into mitochondrial gene editing in human cardiomyocytes, with completion anticipated by May 31, 2029. The project delivers a novel Cas9-based mitochondrial gene editor system (MEDITORS) designed to introduce, regulate, and...
- Federal Grant Award Summary Massachusetts General Hospital received a $1.52 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of June 30, 2029. The award supports the development and validation of mechanomicroscopy, an innovative endoscopic imaging platform designed to enable transbronchial assessment of pulmonary hypertension (PH) due to lung disease...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston University Medical Campus a $2.93 million Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective September 1, 2025 through June 30, 2030 to establish the Framingham Heart Study (FHS) Cardiovascular Biobank and Atlas. The primary deliverables include creation of a systematic postmortem cardiac and blood vessel tissue repository from 208 consented FHS participants with...
- Federal Grant Award Summary Boston Medical Center Corporation received a $2.12 million Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2025, through February 28, 2030. The award supports fundamental research to elucidate endothelial mechanisms regulating hematopoietic stem cell (HSC) extravasation and niche engraftment. The research aims to identify key factors that direct...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $739,474 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 18, 2025, to investigate the anti-fibrotic roles of stress-induced tRNA-derived small RNAs (tDRs) in cardiac fibrosis. The research will be conducted through May 31, 2030, and focuses on characterizing the mechanisms by which ASP-GTC-3' tDR, a regulatory RNA fragment derived from transfer RNA,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $249,000 Project Grant effective April 1, 2026 through March 31, 2029 under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports whole genome sequence interpretation research aimed at discovering new genes and mechanisms associated with coronary artery disease (CAD) and familial hypercholesterolemia (FH). The research addresses the limitation of current genetic diagnostic criteria, which are restricted to previously identified genes and variants, resulting in low diagnostic yield for FH genetic testing. By expanding genomic analysis capabilities, this project seeks to improve early diagnosis and risk stratification for individuals with severe hypercholesterolemia, enabling earlier intervention and better management of CAD progression. The research conducted at Massachusetts General Hospital's Cambridge, MA facility will generate scientific outputs including identification of novel genetic variants associated with lipid metabolism and CAD risk, characterization of new disease mechanisms, and enhanced diagnostic biomarkers to support genotype-based clinical decision-making. These discoveries are expected to advance precision medicine approaches to cardiovascular disease prevention and treatment, directly supporting NHLBI's mission to reduce morbidity and mortality from heart, lung, and blood disorders through evidence-based genetic screening and therapeutic intervention strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 4/2/26 |