The National Heart, Lung, and Blood Institute (NHLBI) awarded a $521,214.63 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Rutgers, The State University of New Jersey, doing business as RBHS-School of Nursing, to conduct research on the "Methylomic and Metabolomic Determinants of Lung Function in Asthmatics". The 3-year project aims to integrate genomic, epigenomic, and metabolomic data to investigate how DNA methylation and metabolite profiles influence lung function trajectories in children with asthma. The research will leverage longitudinal data from three large pediatric asthma cohorts to identify genetic and environmental factors that interact to modulate asthmatic lung function. Key activities include quantitative trait loci mapping, causal inference testing, and network-based integration of multi-omic biomarkers, with the goal of advancing understanding of the molecular underpinnings of asthmatic lung disease progression.
Generated 1/28/25, 10:36 AM