Project Grant R00GM143484
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $582,618 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Ohio State University. The grant supports research to determine the mechanisms by which RNA N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications modulate SARS-CoV-2 replication, gene expression, immunity, and pathogenesis. Key activities include using CRISPR-Cas9 to knock out host RNA m6A...
- The National Institute of General Medical Sciences (NIGMS) awarded a $597,573 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Ohio State University. The grant supports advanced structural and dynamic studies of large protein and protein-nucleic acid complexes and assemblies that play key roles in human health and disease. The research aims to provide atomic-level insights into the structure, dynamics, interactions, and function of nucleosomes,...
- This federal Project Grant award of $658,165 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports advanced research on the effects of ions on mRNA elements, ribosomes, and antibiotic-RNA interactions. The research, led by Triad National Security, LLC, a for-profit limited liability company in Columbus, Ohio, aims to address fundamental questions about ribosome function and tRNA selection, as well as...
- The National Institute of General Medical Sciences (NIGMS) awarded a $370,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the San Diego State University Foundation. The grant, awarded on May 10, 2025, aims to measure and understand the molecular mechanisms of viral nucleocapsid self-assembly and disassembly through a combination of quantitative experimental methods, including interferometric scattering microscopy and cryo-electron microscopy. The...
- The federal Project Grant award of $393,750 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research on lysosomal membrane dynamics and cellular responses to lysosomal damage. The research, conducted by The Ohio State University, aims to uncover a novel cellular process called Lysosomal Tubulation and Sorting driven by LRRK2 (LYTL) that is triggered by lysosomal membrane damage. The project integrates...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $209,122 project grant to The Ohio State University (OSU) on May 1, 2025. The grant, titled "STRIVE: Short-Term Research in Immunology and Virology Experience," aims to expand, diversify, and strengthen the physician and surgeon scientist pipeline in the fields of immunology and virology. Over the 5-year project period...
- This federal Project Grant award, valued at $316,968 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into the regulation, inhibition, and quality control mechanisms of ribosomes. The research aims to advance understanding of translation fidelity, ribosome rescue, and the role of bacterial ribonucleases in regulating ribosomes and causing growth inhibition. The award...
- This federal Project Grant award, valued at $443,806 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at investigating the coordination and collective impacts of multiple enzyme-mediated modifications across distinct RNA species, particularly mRNA, tRNA, and rRNA. The research project, scheduled to be completed by June 2030, seeks to uncover the extent of crosstalk...
- The National Institute of General Medical Sciences (NIGMS) awarded Attogene Corporation, a biotechnology company based in Austin, Texas, a $229,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a rapid, portable, and sensitive test for detecting ribonucleases (RNases). The grant supports the company's efforts to create a novel lateral flow assay prototype that can quickly identify RNase contamination, which is critical for ensuring quality...
- This federal Project Grant award of $854,927, provided by the Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to define the mechanisms of a new pathway for genome stability called RNA Damage Induced DNA Breaks (RDIBS). The research, conducted by The Washington University in Missouri, aims to identify the types of RNA modifications that activate RDIBS, the...
The Ohio State University was awarded a $249,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to investigate the role of host mRNA cleavage by RNase L in viral infections. The research aims to elucidate the relationship between RNase L-mediated host mRNA cleavage and translation, as well as explore the involvement of translation factors in modulating this process. The project will leverage high-throughput sequencing techniques and real-time single-molecule detection to gain a comprehensive understanding of RNase L's function in the cellular response to viral infections. This 3-year research effort, beginning in August 2025, seeks to advance fundamental knowledge in this area and inform the development of potential therapeutic interventions targeting viral infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/21/25 |