Project Grant R00AA029754
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $248,959 to The Medical College of Wisconsin, Inc. to conduct research on the reciprocal relationship between alcohol use and brain function in adolescents and young adults. The 5-year project aims to assess how neurocognitive mechanisms of decision-making and risk-taking in adolescence contribute to alcohol use initiation, escalation, and maintenance,...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $431,918 in funding to Bryant University for a research project focused on understanding the neural circuitry mechanisms underlying maladaptive reward memories related to alcohol addiction. The research aims to use the genetic tractability of the Drosophila melanogaster model organism to investigate how alcohol disrupts memory circuit activity and drives...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $390,454 Project Grant to Envisbio LLC to develop novel therapeutic aptamers targeting phosphodiesterase 4B (PDE4B) for the treatment of alcohol use disorder (AUD). The project aims to identify and characterize PDE4B-specific aptamers that can modulate PDE4B activity, with the goal of advancing these modulators into in vivo testing and eventual human clinical trials for...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $152,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Des Moines University Osteopathic Medical Center (DMU) to study the role of GLUD1 receptors in regulating structural plasticity during chronic ethanol exposure and withdrawal. The two-year grant, awarded on September 1, 2023, will support DMU's research aimed at understanding how GLUD1 receptor function and expression influence dendritic spine...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $2,365,880 to the University of Tennessee Health Science Center to fund a research project titled "Dissecting the Neurobiological Basis of Social Control over Alcohol Self-Administration." The project aims to develop a preclinical model to investigate how social context and alcohol dependence interact to influence alcohol...
- This Project Grant award, totaling $560,108.00 and spanning September 15, 2025 to August 31, 2030, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The purpose of the project is to investigate the neurocognitive mechanisms that promote resilience to alcohol use disorder (AUD) in individuals with a family history of AUD. Specifically, the research will examine how attentional abilities may...
- This federal Project Grant award of $119,253 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research to investigate the impact of third trimester alcohol exposure on memories encoded by sharp-wave ripples in the hippocampal-retrosplenial cortex circuit. The research will use a mouse model, in vivo electrophysiology, and optogenetics to examine how this alcohol exposure affects key features of sharp-wave ripples, such as amplitude...
This $249,000 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) aims to investigate the role of the TARP G-8 protein in regulating AMPA receptor-mediated transmission in key brain regions during dependence-escalated alcohol self-administration. The project, titled "Pathological AMPA Receptor Adaptations Governing Dependence-Escalated Alcohol Self-Administration," will be conducted by researchers at Loyola University of Chicago's Health Sciences Campus over a 3-year period from August 2025 to July 2028. The research seeks to advance the understanding of the underlying neurobiological mechanisms that contribute to alcohol use disorder and inform the development of more effective prevention and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/21/25 |