Project Grant K99HL177314
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $754,729 to the University of Pittsburgh to investigate the mechanisms by which respiratory viral infections, including COVID-19, can lead to persistent lung inflammation and damage. The research aims to understand how viral antigen persistence in pulmonary endothelial cells drives chronic activation of CD8+ T cells, leading to long-term pulmonary sequelae. The...
- This federal Project Grant award of $843,607, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research at the Icahn School of Medicine at Mount Sinai to investigate the link between ischemic cardiac injury and its impact on sleep regulation through an immune-mediated heart-brain axis. The research aims to document the neuroimmune pathways that regulate sleep after myocardial infarction (MI) and the consequential brain-heart outputs...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $402,911 Project Grant to The Trustees of Columbia University in the City of New York to develop a pericardial mRNA therapy for the treatment of myocardial infarction (heart attack). The research aims to create a new anti-inflammatory drug based on previous studies of stem cell derivatives for heart repair, which will be administered via minimally invasive...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $777,954 to the Icahn School of Medicine at Mount Sinai to conduct research on improving preconception cardiovascular health among adolescents. The key products and services to be delivered through this grant include: Constructing a school-based adolescent preconception cohort through data linkages to study the influence of school environments on cardiovascular risk...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Albert Einstein College of Medicine provides $785,198 in funding to study the role of chaperone-mediated autophagy (CMA) in regulating cardiac fibroblast and myofibroblast function during heart repair following myocardial infarction. The research aims to investigate how CMA, a selective protein degradation process, modulates fibroblast phenotypic transitions and impacts...
- The U.S. National Heart, Lung, and Blood Institute awarded a $803,768 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the J. David Gladstone Institutes, a non-profit biomedical research organization in California. The grant funding supports a research project titled "Chromatin Regulation of Immune Cells in Myocardial Inflammation", which aims to elucidate the role of the epigenetic regulator BRD4 in controlling monocyte differentiation and macrophage...
- This federal Project Grant award of $856,791.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the ANKEF1 protein in ciliary function and host defense against influenza virus infection. The research, conducted by the Icahn School of Medicine at Mount Sinai, aims to leverage novel mouse models, human iPSC-derived airway epithelial cultures, and...
- This Project Grant award for $814,387 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting research to investigate the role of a novel subpopulation of innate lymphoid cells (ILC3s) in lung infections and vascular regeneration. The award recipient, The Trustees of Columbia University, will utilize mouse models, single-cell analysis, and in vitro assays to: Define the tissue niche and response dynamics of lung vascular ILC3s (VILC3s),...
- The federal Project Grant award of $507,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop an automated system that integrates micro-electromechanical sensors, automation, and machine vision to simultaneously measure electrophysiological properties and contractile forces in single human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). This innovative system is expected to significantly reduce measurement time...
- This federal Project Grant award of $758,862.00 was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Yale University. The award supports research aimed at preventing cardiac remodeling and progressive heart failure following myocardial infarction (MI). Key objectives include developing a percutaneous, image-guided approach to deliver hydrogels of varying stiffness to the infarcted and peri-infarcted myocardium. This is intended to...
This Project Grant award in the amount of $167,940 was provided by the National Heart Lung and Blood Institute (CFDA# 93.837 Cardiovascular Diseases Research) to the Icahn School of Medicine at Mount Sinai to support research investigating the impact of pulmonary influenza infection on the pathogenesis of myocardial infarction and heart failure. The project aims to comprehensively probe the hypothesis that influenza A virus translocates from the lung to the heart, inducing an antiviral response that damages the heart and increases susceptibility to cardiovascular disease. The research will utilize innovative mouse models to study the effects of pulmonary influenza infection on the heart, as well as how underlying infection alters the pathogenesis and severity of myocardial infarction. This award is expected to run from August 10, 2025 through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $167.9k | 8/6/25 |