This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $504,596 to investigate the molecular mechanisms by which the bacteria Wolbachia pipientis interacts with and manipulates its insect host. The primary objectives of this 5-year research project are to: 1) identify the specific host targets of Wolbachia's ankyrin repeat proteins, 2) determine the relevance of these...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $125,250 to Harvard T.H. Chan School of Public Health to conduct research on harnessing Wolbachia-induced conditional infertility for control of the malaria mosquito. The goal is to elucidate the mechanisms regulating Wolbachia infections in Anopheles mosquitoes, which transmit malaria, in order to generate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $783,961 to The Johns Hopkins University to investigate the mechanisms underlying mosquito infectiousness in malaria. The key objectives are to determine the inocula associated with low- and high-infected mosquitoes using both rodent and human malaria parasites, as well as compare the quality of sporozoites...
This $600,618 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the molecular mechanism of a male-killing gene found in the Wolbachia bacteria. The project aims to test the hypothesis that the Wolbachia WMK protein kills male embryos by disrupting host transcription and gene expression during early embryogenesis through DNA binding and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $211,038 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Johns Hopkins University to conduct research on targeting a reductive dehalogenase enzyme as a novel strategy for controlling mosquito populations and mitigating vector-borne diseases. The research aims to examine the biological role of the dehalogenase enzyme in insects, particularly how it protects fruit flies from the accumulation...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $760,318 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, Davis. The project aims to develop recombinant enhanced antiviral sensors (REAVRS) that combine virus-sensing domains with effector domains from different antiviral proteins to create broadly-acting antiviral agents. The key objectives are to: 1) generate and optimize REAVR proteins and evaluate their...
This $512,581 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), to Iowa State University of Science and Technology. The grant will fund research to examine the influence of prostaglandin E2 (PGE2) on innate immune function in the mosquito Anopheles gambiae. The research aims to provide fundamental insights into the mechanisms of PGE2 regulation, immune cell...
This federal Project Grant award in the amount of $198,724.00 was made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program led by the University of California, Santa Cruz that seeks to understand the functional genetic basis of the symbiotic relationship between the bacteria Wolbachia and the fruit fly Drosophila melanogaster. Key research objectives include: revealing the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $648,924 to Iowa State University of Science and Technology to conduct research on the role of mosquito extracellular vesicles in malaria parasite killing and immune priming. The overall objective is to obtain a mechanistic understanding of how mosquito extracellular vesicles influence mosquito immune function,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $787,043 to Cornell University to conduct research on the evolutionary history and symbiotic relationships between opportunistic fungal pathogens and their endosymbiotic bacteria. The key objectives are to elucidate population-level processes governing these fungal-bacterial symbioses, including the role of...