Project Grant K99AG090739
- The Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $152,324 to The Leland Stanford Junior University to define the role of CXCL13 as an aging-associated defect in memory T cell homeostasis. The project, led by Dr. Casey Beppler, will leverage human immune organoid technology to reveal the mechanism of CXCL13-mediated maintenance of memory T cells (Aim 1) and determine the specific T cell...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $418,000.00 to Western Michigan University Homer Stryker M.D. School of Medicine to elucidate the role of B cells in the pathophysiology of aging. The study aims to analyze the immunoglobulin repertoire of B cells in the cerebral spinal fluid (CSF) compared to peripheral blood B cells, to determine if peripheral B cells migrate to the central nervous system in older individuals. This...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $356,174 to The Regents of the University of California, San Francisco (UCSF) to conduct in vivo testing of structure-based vaccine candidates targeting Alzheimer's disease. The goal is to determine the efficacy of an active immunization strategy in preserving cognitive and neural function by slowing the formation of amyloid-beta or tau protein aggregation in the brain. The research will use...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to support research on the cell-specific roles of CD153 and CD30 in regulating immune responses, particularly in the context of aging and immune function. The $441,375 award covers the period from Aug 1, 2025 to Jul 31, 2027 and was granted to the Children's Hospital Medical Center in Cincinnati,...
- This $428,397 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year research study on the anatomical and functional characteristics of the thymus in the elderly human population. The research team at the University of Pikeville will conduct qualitative and quantitative assessments of thymic structure and function in cadaver samples, using techniques such as immunohistochemistry and molecular biology to determine the degree of thymic...
- This federal Project Grant award of $190,278.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the role of transposable elements in septic immune aging. The research aims to 1) examine the dynamics of transposable element de-repression as a function of age and sepsis, and 2) employ machine learning to quantify immune aging and identify specific transposable elements...
- This Project Grant award of $451,000.00 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will fund research to understand how aging and chronic lymphocytic leukemia (CLL) impact the metabolic function of T cells. The goal is to develop strategies to rescue T cell aging and improve the production of chimeric antigen receptor (CAR) T cells from elderly cancer patients. The award will support cutting-edge metabolism assays to evaluate the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This federal Project Grant award of $246,750 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a research study on the "Transcriptional and Functional Identity of Human T Follicular Helper Cells Across Tissues". The project aims to conduct a systematic analysis of human T follicular helper (Tfh) cells across lymphoid and mucosal tissues, including the lung, in order to define how T cells influence...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, provides $127,019 to the University of California, Irvine to conduct research aimed at understanding how aging impacts T follicular helper cells (Tfh) and their role in the decline of vaccine-induced antibody responses in older adults. The key objectives are to use a systems immunology approach to quantify age-associated changes in Tfh heterogeneity in secondary lymphoid organs, and to identify Tfh features that correlate with declining antibody quality following influenza vaccination in older adults. This will involve integrating transcriptomic, epigenomic, and phenotypic analyses, as well as leveraging a novel in vitro human tonsil organoid model. The findings from this research could provide insights into rejuvenating the aging germinal center and improving vaccine efficacy in older populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $127.0k | 8/26/25 |