Project Grant K76AG095109
- This $458,698 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at the University of Michigan to identify cellular and molecular mechanisms underlying therapy resistance and disease relapse in acute myeloid leukemia (AML). The project aims to characterize genes and pathways that confer growth advantages to leukemic stem cells, enabling them to persist and regenerate disease after initial clinical remission. This 5-year...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $339,038 to the University of Pittsburgh to study the prevalence and impact of frailty in older adults with polymyalgia rheumatica (PMR). The award period runs from Sep 15, 2024 to Aug 31, 2026. The key objectives are to: 1) Determine the association of frailty with glucocorticoid duration and prescription analgesic use in older adults with PMR, and 2) Examine the association of physical...
- This Project Grant award of $451,000.00 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will fund research to understand how aging and chronic lymphocytic leukemia (CLL) impact the metabolic function of T cells. The goal is to develop strategies to rescue T cell aging and improve the production of chimeric antigen receptor (CAR) T cells from elderly cancer patients. The award will support cutting-edge metabolism assays to evaluate the...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $483,760 to The Trustees of the University of Pennsylvania to conduct research on understanding the role of the DCAF15 protein in acute myeloid leukemia (AML). The primary objectives are to (A) decipher the biological function of DCAF15 in myeloid development and leukemia in vivo, (B) investigate the role of cohesin acetylation in AML pathogenesis, and (C) develop small molecule...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $734,435.00 in funding to the Beckman Research Institute of the City of Hope to conduct research aimed at overcoming resistance to BH3 mimetic drugs in the treatment of acute myeloid leukemia (AML), particularly in older patients. The key objectives are to define the molecular mechanisms underlying BH3 mimetic resistance in AML and evaluate whether targeting the ADSS2 enzyme,...
- This federal Project Grant award of $641,856 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to determine the effects of reduced nursing home capacity on older adults, their caregivers, and post-acute/long-term care access. The project, which runs from September 1, 2025 to May 31, 2030, will conduct rigorous quantitative analyses to assess the implications of nursing home capacity declines, which have accelerated due to the COVID-19 pandemic. The...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) supports research at the University of Texas MD Anderson Cancer Center to investigate the role of targeting the ATPases BRG1/BRM in the treatment of acute myeloid leukemia (AML). The $542,663 award, provided from April 2025 through March 2030, will fund preclinical studies on the efficacy of two novel targeted agents, FHD-286 and AU15330, to treat AML with MLL rearrangement or mutant NPM1,...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), aims to study the impact of frailty on disease relapse and therapy intensity in older adults with acute myeloid leukemia (AML). The $243,000 award to the University of Pennsylvania will support research to identify biomarkers and develop treatment selection strategies for this population. The project, running from September 2025 to May 2030, seeks to address the significant disparity in AML outcomes for older adults, who often cannot tolerate high-intensity treatments. Key deliverables include advancing understanding of the relationship between frailty, disease relapse, and treatment intensity, as well as evaluating the use of intermediate-intensity therapies like azacitidine and venetoclax for this patient population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $243.0k | 9/5/25 |