Project Grant K23AI185318
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on July 24, 2025. The grant will fund structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2, the virus that causes COVID-19. The goal is to determine the high-resolution structure of the full-length N protein in complex...
- This federal Project Grant award of $1,442,898.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the effects of vaccination on outcomes of acute and post-acute respiratory viral infections, including COVID-19, in solid organ transplant recipients. The research aims to better understand the risks of severe respiratory viral infections and associated post-acute syndromes...
- This $858,186 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project titled "Decoding T Cell Clonotypes, Biology and Predictive Biomarkers Associated with Immune Checkpoint Myocarditis." The project aims to investigate the mechanisms underlying immune-related myocarditis, a potentially fatal adverse event associated with immune checkpoint inhibitor cancer therapies. Using...
- This $489,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), supports research to overcome technical obstacles in understanding the assembly and regulation of B cell antigen receptors (BCRs). The award aims to develop effective adaptive immunity following infection and vaccination by engineering appropriate cell lines and utilizing native membrane environments to study BCR...
- The National Institutes of Health National Institute of Allergy and Infectious Diseases awarded a $1,074,434.37 Project Grant to the Massachusetts General Hospital under the Allergy and Infectious Diseases Research program (CFDA 93.855) on March 17, 2021 with a completion date of July 12, 2021. The grant funding supports research to develop protocols to induce tolerance in non-human primate heart allograft recipients without chronic immunosuppression. The awardee will test approaches to either...
- The University of Maryland, Baltimore received a $427,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study CD27-mediated immune suppression by hematopoietic stem and progenitor cells (HSPCs), innate immune cells, or non-hematopoietic cells. The research aims to understand how the CD27-CD70 pathway regulates HSPC differentiation and function, and its potential role in modulating allogeneic T cell...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $801,363 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the New York Blood Center, Inc. to study the immune and behavioral responses of transgender women to seasonal COVID-19 vaccines. The goal is to understand how exogenous sex hormones from gender-affirming hormone therapy impact immune responses and vaccination outcomes in this population, which could help...
- This federal Project Grant award, valued at $459,439.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research aimed at improving the understanding of alloreactivity, the immune response that leads to acute cellular rejection of transplanted tissues. The research seeks to identify the specific peptide-HLA complexes recognized by alloreactive T cells, which could...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $883,119 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute to develop a novel mRNA vaccine and immunotherapy against hepatitis B virus (HBV) infection. The award supports research to investigate viral and cellular factors that hinder effective antigen expression and improve vaccine antigens to elicit potent antibody and T cell responses to cure HBV...
- This $832,910 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify immune factors associated with risk of cytomegalovirus (CMV) disease in orthotopic liver transplant recipients. The University of Washington is the primary awardee, with the goal of developing a clinically useful measure of CMV disease risk to guide prevention efforts. The research focuses on...
This $194,400 project grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to characterize the relationship between donor and recipient SARS-CoV-2 immunity in allogeneic hematopoietic stem cell transplant (HCT) patients. The study, conducted by Brigham & Women's Hospital, will evaluate the humoral and cellular immune responses to SARS-CoV-2 mRNA vaccines in HCT recipients to inform new vaccination strategies for this high-risk population. The project will focus on analyzing the transfer of immunity from matched-related donors to recipients post-transplant, as well as the correlation between donors' pre-harvest cellular responses and recipients' post-transplant humoral vaccine responses. These findings will provide critical insights to protect HCT patients and reduce viral reservoirs that could enable the generation of new SARS-CoV-2 variants.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.4k | 9/15/25 |