Project Grant K22AI184752
- Federal Grant Award Summary The University of Rochester received a $415,250 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 7, 2025, with a completion date of June 30, 2027. The award supports investigator-initiated biomedical research focused on understanding the immunological mechanisms of viral respiratory infections, specifically examining how long-lived highly differentiated...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Rochester a Project Grant totaling $1,042,346 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective January 28, 2026, with completion targeted for December 31, 2030. This research initiative, titled "Critical Developmental Windows and Underlying Processes in Extremely Low Gestational Age Neonates' Immune Trajectories," aims to identify key...
- Federal Grant Award Summary Cornell University, through its Office of Sponsored Programs, received a $591,368 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 11, 2025, with a completion date of July 31, 2030. The award supports fundamental research aimed at understanding the epigenetic regulation of natural killer (NK) cell memory, with particular focus on...
- Federal Grant Award Summary The University of Rochester received a $226,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025 through June 30, 2027. This award funds research investigating novel mechanisms of CD4-independent immunity against Pneumocystis pneumonia (PCP), a life-threatening fungal respiratory infection affecting immunocompromised patients. The...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Rochester a Project Grant totaling $525,095 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigative research on human cytomegalovirus (HCMV) cellular infection mechanisms. Awarded on July 10, 2025, with a completion date of June 30, 2030, this research initiative will deliver scientific findings addressing HCMV's substantial...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $345,650 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on May 26, 2025, for completion by November 30, 2027. This Project Grant funds basic biomedical research investigating the role of chromatin-associated RNA processing in early B-cell development, specifically examining...
- Federal Grant Award Summary Cornell University received a $238,810 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2025, through August 31, 2027. The award supports investigator-initiated biomedical research examining the embryonic origins of T cells (T lymphocytes), specifically aimed at characterizing how different progenitor cell populations in early life...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $899,850 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Whitehead Institute for Biomedical Research, effective February 20, 2026, through January 31, 2031. This award supports fundamental research aimed at elucidating the molecular mechanisms by which apicomplexan parasites recognize and invade host cells—a critical process for parasite survival...
- Federal Grant Award Summary The University of Chicago received a $3.02 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with completion targeted for June 30, 2029. This award supports investigator-initiated biomedical research focused on elucidating the role of BRWD1-mediated cohesin conversion in B cell biology and function. The research examines how...
- Federal Grant Award Summary Duke University's Office of Research Administration received a Project Grant award of $127,527 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective November 1, 2025, with a completion date of April 30, 2028. The award supports investigator-initiated biomedical research focused on defining the role of the RGS12 locus in macrophage function, specifically examining how...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Rochester a $162,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. This award supports research investigating the role of genome organization in conventional dendritic cell type 1 (cDC1) development, with the objective of elucidating how epigenetic mechanisms control cDC1 differentiation and terminal maturation. The research leverages preliminary findings demonstrating that cohesin, a protein complex responsible for three-dimensional genome organization, is essential for optimal cDC1 development. The funded research will deliver a comprehensive characterization of cohesin-dependent transcriptional and chromatin remodeling mechanisms through multiple integrated analytical approaches. Deliverables include single-cell RNA sequencing (scRNA-seq) and chromatin accessibility analysis (scATAC-seq) to map aberrant differentiation trajectories in cohesin-deficient dendritic cells; chromatin conformation capture (Hi-C) and cut and run (CUT&RUN) assays to examine histone post-translational modifications; and targeted investigation of the ID2 locus using CRISPR/Cas9 technologies. These research outputs are intended to advance understanding of the chromatin-level control mechanisms governing cDC1 development, with potential applications toward improving dendritic cell-based immunotherapies for infectious diseases and other medical conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $162.0k | 4/1/26 |