The National Institute of Mental Health (NIMH) awarded a $196,875 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Ohio State University to conduct research on "Digital Monitoring of Emotion Regulation and Suicidal Ideation Among Individuals at Clinical High Risk for Psychosis". The 2-year study aims to examine emotion regulation as a mechanism for suicidal ideation in individuals at clinical high risk for psychosis, using ecological momentary assessment, wearable...
This $793,161 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a 5-year experimental study to investigate the relationship between nocturnal wakefulness and suicide risk factors. The University of Arizona, the prime awardee, will recruit 90 adults with recent suicidal ideation to participate in laboratory-based assessments of cognitive processes and affect at different times of day, as well as...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a research project to elucidate the glutamatergic mechanisms by which repetitive transcranial magnetic stimulation (rTMS) exerts its antidepressant effects. The $198,728 award, effective February 11, 2025, supports the use of cutting-edge ultra-high field (7T) neuroimaging techniques, including glutamate chemical exchange saturation transfer...
The National Institute of Mental Health (NIMH) awarded a $206,875 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Research Foundation For Mental Hygiene, Inc. (RFMH) to investigate the impact of GRIN2B/GLUN2B disruption on dopaminergic function and related behaviors. The project aims to use a conditional Cre/Lox strategy in mice to assess the effects of diminished GLUN2B signaling on dopaminergic neuron firing, dopamine release, and downstream behaviors such as impulsivity and...
This $1,955,745 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will fund a 4-year study to measure and map trajectories of risk and resilience for suicidal thoughts and behaviors among sexual and gender minority (SGM) preteens. The study aims to: 1) develop consensus on best practices for safely and effectively sampling, recruiting, and retaining high-risk SGM preteens into research; 2) create and pretest an...
This Project Grant award of $1,135,986, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to clarify suicide risk phenotypes among preteen youth aged 8-12 years old. The primary objectives are to: Adapt an existing measure of suicide risk for use with preteens, incorporating expert and stakeholder input to ensure cultural and developmental appropriateness. Use the new measure to establish phenotypes of...
This Project Grant award of $2,220,017.04 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of the molecular and cellular networks in the mood regulation circuitry of major depressive disorder (MDD). The overarching objective is to generate single-cell transcriptomic profiles to study molecular changes, including those specific to genetic ancestry and sex, associated with MDD...
The National Institute of Mental Health (NIMH) awarded a $904,100 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Lovelace Biomedical Research Institute in Albuquerque, New Mexico. The grant, awarded on May 5, 2025, will fund a longitudinal study to develop algorithms that predict mental health functioning and related outcomes, such as recidivism and substance use relapse, in incarcerated women. The research will utilize multimodal data, including psychosocial,...
The National Institute of Mental Health (NIMH) awarded a $1,401,862 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the University of California, Berkeley. The 5-year grant, which commenced on September 21, 2024, will support research to investigate the role of the orbitofrontal cortex (OFC) in inhibiting habitual responses in the striatum to enable goal-directed decision-making. The researchers will use a novel behavioral task and advanced neural recording...
The National Institute of Mental Health (NIMH) awarded a $197,576 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to the University of California, San Diego (UCSD) for the project "Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression (COMBAT-SI)". The project aims to investigate cortical inhibition as a biological target of...