Project Grant K08HL179453
- This Project Grant award of $629,319.00 from the National Heart Lung and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) supports research by Emory University to investigate cellular mechanisms for overcoming refractory cystic fibrosis defects. The research aims to identify ribosomal proteins that can partially rescue the synthesis and assembly of cystic fibrosis transmembrane conductance regulator (CFTR) protein variants with premature termination codons, which are associated...
- This federal Project Grant award of $441,375.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop and optimize a dual adeno-associated virus (AAV) system with intein technology to deliver full-length, functional cystic fibrosis transmembrane conductance regulator (CFTR) protein to airway epithelial cells of cystic fibrosis (CF) patients. The goal is to restore CFTR function in CF patients, particularly those...
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to understand the mechanisms linking the cystic fibrosis transmembrane conductance regulator (CFTR) gene to dysregulated barrier function, insulin receptor function, and glucose transport in the lungs of cystic fibrosis (CF) patients. The $730,494 award to Emory University, with a sub-award to Vanderbilt University Medical Center, aims to investigate...
- The federal Project Grant award of $730,268.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Icahn School of Medicine at Mount Sinai. The funding will support the development of a versatile paired prime editing toolkit to correct mutations in the CFTR gene, which is the primary cause of cystic fibrosis and associated with other genetic diseases. The research aims to replace defective CFTR exons with corrected...
- The Project Grant award of $564,121 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to develop peptide surface-functionalized lipid nanoparticles (PepLNPs) for pulmonary delivery that can reach airway basal cells and use base editing technology to correct specific CFTR gene mutations associated with cystic fibrosis. The goal is to achieve permanent correction of lung disease in cystic fibrosis patients through one-time,...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides funding of $374,576 from September 5, 2025 to August 31, 2027 to Louisiana State University Health Sciences Center New Orleans. The grant supports research to investigate the role of neutrophils, a type of immune cell, in the pathogenesis of cystic fibrosis (CF). The research aims to elucidate how CFTR, the gene mutated in CF, impacts neutrophil function and the...
- This federal Project Grant award of $551,863 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on how prostaglandin E2 (PGE2) regulates airway epithelial cells to balance liquid absorption and secretion. The research aims to establish new regulatory mechanisms controlling airway surface liquid volume, with the goal of identifying novel therapeutic targets for pulmonary diseases. The project is conducted by researchers at the...
- This federal Project Grant award, totaling $756,875.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Cincinnati. The award supports research to investigate the fundamental mechanisms by which neutrophil extracellular traps (NETs) contribute to airway damage and infection in mucoobstructive lung diseases, such as cystic fibrosis. Key research aims include examining how NET-mediated...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate the role of a Pseudomonas bacteriophage (PF phage) in promoting chronic biofilm lung infections in individuals with cystic fibrosis. The $192,672 award, effective from September 1, 2025 to August 31, 2030, will support research at Stanford University to study how the PF phage mediates...
The federal Project Grant award titled "Carbonic Anhydrase Mediated Regulation of Microtubule Dynamics and Infection in Cystic Fibrosis" is funded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) in the amount of $163,080. The award, with a period of performance from September 1, 2025 to August 31, 2030, aims to investigate how impaired microtubule dynamics and intracellular transport, exacerbated by reduced carbonic anhydrase expression, contribute to increased bacterial adhesion in cystic fibrosis. The research project, conducted by the Ann & Robert H Lurie Children's Hospital of Chicago, will use advanced live cell imaging, biochemical assays, proteomics, and microbial adherence studies to test hypotheses across three specific aims focused on the role of carbonic anhydrases in intracellular transport, membrane organization, and bacterial infection in cystic fibrosis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $163.1k | 9/10/25 |