Project Grant K08HL179396
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to support a mentored implementation science research program focused on improving asthma care and outcomes for children from marginalized communities. The $120,363 award, effective August 18, 2025, will fund Dr. Michelle Eakin's efforts to expand her mentoring program in patient-oriented implementation science. The project will leverage ongoing data collection...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $189,000 Project Grant under CFDA #93.837 Cardiovascular Diseases Research program to the University of Colorado-Denver. The 2-year grant, with a period of performance from September 15, 2025 to August 31, 2027, will support research to investigate the role of outdoor air pollution and environmental allergens in driving treatment response in children with acute asthma...
- This $691,124.00 project grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research on the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The project aims to test the hypothesis that persistent circadian disruption, including misaligned sleep, eating, and activity timing, will be related to the development of cardiometabolic risk through epigenetic...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate how early-life inflammation and viral infections shape the development and function of type 2 innate lymphoid cells (ILC2s) in the lungs, and their role in driving childhood asthma susceptibility. The $740,709 award to the University of Utah is intended to define the cellular and molecular mechanisms by...
- This Project Grant award for $355,935 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) supports the development of a novel, oral immunoregulatory therapeutic for the treatment of asthma. The primary objectives are to characterize the therapeutic efficacy and dosing regimen of the compound in mouse models of asthma, and to evaluate its ability to modulate immune function and suppress inflammation in human...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $731,130 to the Children's Hospital Medical Center to conduct a study titled "Improving Medication Adherence Using an Adaptive mHealth Intervention in Adolescents with Asthma". The study aims to evaluate the effectiveness of a stepped-care mHealth intervention for improving adherence to daily inhaled corticosteroids in adolescents with asthma. The...
- This $680,562 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research investigating the long-term lung epithelial alterations resulting from early-life respiratory syncytial virus (RSV) infection. The research aims to determine the mechanisms by which early-life RSV infection predisposes individuals to developing asthma later in life, focusing on the role of innate cytokines like IL-1β and IL-33 in driving...
- The federal Project Grant award of $732,225 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on "Mitochondrial Mechanisms in Asthma" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. This multi-year (2025-2029) project aims to investigate how variations in the mitochondrial genome influence asthma risk and pathophysiology through alterations in mitochondrial bioenergetics and...
- This federal Project Grant award of $133,221 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to investigate mechanisms underlying chronic inflammatory airway diseases such as chronic rhinosinusitis and asthma. The research aims to develop computational approaches to inform new treatment and prevention strategies for these prevalent, costly conditions....
- This Project Grant award of $427,256 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a randomized, controlled trial to evaluate the use of Bilevel Positive Airway Pressure (BPAP) for managing severe asthma exacerbations in children. The key objectives are to: 1) develop a consensus-based protocol for ED BPAP administration and use of other asthma therapies, 2) determine a primary outcome measure for a future multi-center trial, and 3)...
This Project Grant award of $154,980 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Seattle Children's Hospital to investigate circadian regulation of epithelial immune responses in asthma. The key activities include: Measuring viral replication and innate immune responses in airway epithelial cell cultures from healthy donors and pediatric asthma patients in relation to cellular circadian time. Comparing circadian gene expression patterns in airway epithelium between children with asthma and healthy controls. Characterizing the impact of circadian disruption on epithelial immune responses to viral infection. This research aims to advance understanding of how circadian rhythms influence asthma pathophysiology, with the goal of identifying new therapeutic strategies for managing viral infections and asthma exacerbations. The project will leverage an existing biorepository of primary human airway epithelial cells and run from Sep 2025 through Aug 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.0k | 8/23/25 |