Project Grant K08HL164881
- NSF POSTDOCTORAL FELLOWSHIP IN BIOLOGY FY 2021: USING METACOMMUNITY THEORY TO ASSESS THE IMPACT OF MULTI-SPECIES INTERACTIONS ON GUT MICROBIAL ASSEMBLY This $138,000 Project Grant from the National Science Foundation Division of Environmental Biology will fund research from January 1, 2022 to December 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise...
- Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Leland Stanford Junior University a $386,844 Project Grant effective August 1, 2025, through April 30, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This K23 Mentored Patient-Oriented Career Development Award supports research led by Dr. Ruben Colman, MD, PhD, investigating the relationship between microbial metabolites and anti-TNF (tumor...
- Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $173,664 Project Grant to the University of California, San Francisco (UCSF) on August 7, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This five-year research award, with a completion date of July 31, 2030, supports molecular characterization of ascites fluid to identify drivers of infection in patients with decompensated cirrhosis. The...
- This Project Grant, awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), provides $1,080,800 in federal funding to The Leland Stanford Junior University to advance translational microbiome science focused on the human small intestinal (SI) microbiota. Awarded September 5, 2025, with completion targeted for August 31, 2030, the grant supports the development of a comprehensive species atlas that characterizes the...
- Federal Project Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $2,177,874 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2025 through February 28, 2029. The award supports basic and translational research investigating the mechanisms by which gut microbe-derived lipids regulate chronic inflammation in cardiometabolic diseases,...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $807,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2025, with a completion date of February 28, 2030. The award funds a prospective longitudinal cohort study designed to investigate the relationship between gut and blood microbial signatures and immune dysfunction in...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Boston Children's Hospital a $168,900 project grant effective July 15, 2025, through May 31, 2029, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research initiative investigates the mechanistic pathways by which Blautia species—commensal bacteria—activate enteroendocrine cells to produce satiety hormones and support gastrointestinal...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $129,619 to the University of Colorado-Denver on September 1, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds a five-year research project extending through May 31, 2030, investigating the interactions between gut microbiome composition, intestinal development, and metabolic health outcomes in offspring...
- Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Rutgers The State University of New Jersey $235,500 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) through a Project Grant mechanism. The award, effective September 15, 2025, through September 14, 2027, funds research investigating gut microbial functions that influence Crohn's disease risk in both multiplex (multi-affected family) and...
- Federal Grant Award Summary Harvard College received a $421,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on the relationship between the human gut microbiome and metabolic health. The award, effective September 1, 2025, through June 30, 2030, supports experiment-based research designed to decipher how lifestyle factors—including diet, exercise, and social...
THE ROLE OF THE BIFIDOBACTERIUM GUT MICROBIOME GUILD IN PATHOPHYSIOLOGY OF CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION - PROJECT SUMMARY/ABSTRACT THE CANDIDATE'S LONG-TERM CAREER GOAL IS TO LEAD AN INDEPENDENT RESEARCH PROGRAM FOCUSED ON DEFINING MECHANISMS THAT GOVERN GUT MICROBIOME-HOST INTERACTIONS IN CHRONIC HEART FAILURE AND TO TRANSLATE THIS KNOWLEDGE INTO NOVEL PREVENTATIVE AND THERAPEUTIC TARGETS. THIS RESEARCH PROGRAM WILL PAVE THE PATH FOR GUT MICROBIOME-FOCUSED PRECISION MEDICINE APPROACHES IN HEART FAILURE. THE CANDIDATE WILL USE THE STRUCTURED ENVIRONMENT OF THE K08 AWARD TO ACQUIRE ADVANCED RESEARCH EXPERTISE IN MICROBIOME META-TRANSCRIPTOMIC AND TIME-SERIES ANALYSES, INTEGRATIVE MULTI-OMIC DATA ANALYSIS, CLINICAL RESEARCH METHODS, AS WELL AS TARGETED PROFESSIONAL DEVELOPMENT SKILLS IN MENTORSHIP, SCIENTIFIC COMMUNICATION, GRANTSMANSHIP, AND LEADERSHIP. THIS WILL BE ACCOMPLISHED IN THE CONTEXT OF INVESTIGATING LONGITUDINAL GUT MICROBIOME-HOST INTERACTIONS IN CHRONIC HEART FAILURE AND HOW THESE RELATE TO DISEASE PATHOPHYSIOLOGY AND PROGRESSION. THE CANDIDATE WILL LEVERAGE A LONGITUDINAL MULTI-OMIC AND CLINICAL DATASET FROM A COHORT OF 60 PATIENTS WITH CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION, PREVIOUSLY RECRUITED BY THE CANDIDATE AS PART OF HER NHLBI-FUNDED F32. THE FIRST AIM WILL EXAMINE THE RELATIONSHIP BETWEEN GUT MICROBIAL BIFIDOBACTERIUM- BASED FUNCTIONAL GUILD AND HEART FAILURE SEVERITY AND OUTCOMES. THE SECOND AIM WILL ELUCIDATE SHIFTS IN THE HOST IMMUNE PROFILE, GUT MICROBIOME COMPOSITION AND FUNCTION, AND HEART FAILURE DISEASE STATUS FOLLOWING A TARGETED BIFIDOBACTERIUM PROBIOTIC INTERVENTION. A NEW COHORT OF PATIENTS WITH STABLE CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION WILL BE RECRUITED FOR THIS AIM. THIS PROJECT WILL UNCOVER MECHANISMS BY WHICH THE GUT MICROBIOME INTERACTS WITH DIFFERENT FACETS OF HOST BIOLOGY, WHICH IS EXPECTED TO PROVIDE NOVEL INSIGHT INTO DISEASE PATHOPHYSIOLOGY AND EXPLAIN HETEROGENEITY IN HEART FAILURE PROGRESSION. THIS KNOWLEDGE WILL TRANSLATE INTO BETTER DISEASE RISK STRATIFICATION AND IDENTIFY NEW THERAPEUTIC TARGETS IN HEART FAILURE. THE PROPOSED PROJECT WILL BE PERFORMED UNDER THE GUIDANCE OF AN EXPERT MENTORSHIP TEAM COMPRISED OF WORLD- LEADING EXPERTS IN HOST-MICROBIOME MULTI-OMICS (DR. SNYDER), MECHANISTIC MICROBIOME RESEARCH (DRS. SONNENBURG AND TANG), AND HEART FAILURE TRANSLATIONAL RESEARCH AND CLINICAL TRIALS (DRS. TANG AND KHUSH). THEY WILL PROVIDE COMPLEMENTARY EXPERTISE IN SKILLS APPLIED IN THIS PROJECT AND SUPPORT THE CANDIDATE'S CAREER DEVELOPMENT. THE RICH MULTIDISCIPLINARY ENVIRONMENT AT STANFORD IS OPTIMAL FOR THIS RESEARCH PROPOSAL AND PROVIDES AN IDEAL SETTING FOR THE CANDIDATE'S DEVELOPMENT INTO AN INDEPENDENT RESEARCHER. AT THE CULMINATION OF THIS PROPOSAL, THE CANDIDATE WILL GAIN THE NECESSARY EXPERTISE AND PRELIMINARY DATA FOR AN R01 PROPOSAL TO IDENTIFY SYNERGISTIC MICROBIOME-HOST PATHWAYS THAT UNDERLIE HEART FAILURE PATHOPHYSIOLOGY. AS AN INDEPENDENT PHYSICIAN-SCIENTIST, THE CANDIDATE WILL USE GUT MICROBIOME-BASED PRECISION MEDICINE APPROACHES TO IMPROVE THE OUTCOMES OF PATIENTS SHE CARES FOR AS A HEART FAILURE PHYSICIAN.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $166.0k | 5/19/25 | ||
| Not listed | $166.0k | 12/11/23 | ||
| Not listed | $166.0k | 12/11/23 |