This Project Grant award, issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $166,644 to support a 5-year research project led by Dr. Rossana Calderon at Columbia University.
The project aims to investigate the modulatory effects of the retinoid-related protein RBP2 on intestinal endocrine cells (EECs) and their hormone secretion. Specific research objectives include: 1) determining how RBP2 impacts EEC proliferation, migration, and survival, and 2) examining RBP2 and retinoid actions in modulating EEC populations, subtypes, and hormone secretion. The research will leverage specialized mouse models and cell/organoid culture lines to characterize changes to EEC dynamics and hormone expression. Findings from this project are expected to provide novel insights into the physiological regulation of EECs, which could help advance therapeutic strategies targeting these important metabolic cells.
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