The University of Colorado-Denver was awarded a $122,387 Project Grant under the National Heart, Lung, and Blood Institute's (NHLBI) Cardiovascular Diseases Research program (CFDA 93.837) beginning on January 1, 2025. The grant supports a research project titled "MIR-301B INHIBITS AUTOPHAGY BY DIRECTLY TARGETING RAB5A" that aims to investigate the role of microRNA-301B in regulating autophagy and apoptosis in pediatric dilated cardiomyopathy. The key objectives are to: 1) Determine the expression of autophagy-related proteins in pediatric dilated cardiomyopathy heart tissue, 2) Establish the effects of microRNA-301B overexpression on autophagy and apoptosis in primary cardiomyocytes, and 3) Evaluate the in vivo regulation of cardiac autophagy by microRNA-301B and its impact on cardiac function in a neonatal mouse model. This research seeks to advance the understanding of age-specific mechanisms underlying heart failure in children and inform the development of novel therapeutic strategies.
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