The Toiyabe Indian Health Project, Inc. was awarded a $500,000 Project Grant by the Department of Health and Human Services Indian Health Service under the Demonstration Projects for Indian Health (CFDA 93.933) program. The grant will fund a five-year initiative to combat the opioid crisis in the rural Inyo and Mono County tribal communities within Toiyabe's service area. The key activities to be delivered include: 1) increasing public awareness and education about opioid misuse, 2) creating comprehensive support teams, 3) expanding access to medication-assisted treatment (MAT) and medication for opioid use disorder (MOUD) treatment, and 4) increasing harm reduction activities. This grant builds upon Toiyabe's previous efforts under the Community Opioid Intervention Prevention Program (COIPP) to address the significant impact of the opioid epidemic on Native American populations in this frontier region of California. Toiyabe will utilize its established healthcare infrastructure and staff expertise to implement this comprehensive, culturally tailored approach to address opioid use disorder and prevent overdoses.