The National Cancer Institute awarded a $632,300 Project Grant (CFDA 93.396 - Cancer Biology Research) to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system for cancer research. The award period is from April 1, 2025 to March 31, 2030. The proposed system will combine a multiscale fluorescence mesoscope with magnify expansion microscopy to enable rapid, large-area 3D imaging of the tumor microenvironment at subcellular...
This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
The National Cancer Institute (NCI) awarded a $877,856 Cooperative Agreement under the Federal Grant Program "Cancer Biology Research" (CFDA 93.396) to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The objective of this 5-year project is to develop the Galaxy for Cancer (Galaxy-C) computational platform to address technical challenges faced by cancer researchers in data analysis and computational infrastructure. The key products and...
This $328,574 Project Grant award from the Defense Health Agency's Military Medical Research and Development (CFDA 12.420) program supports research by the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The grant funds a project to quantify the spatial properties of immunosuppressive macrophages in papillary renal cell carcinoma, with a performance period from July 1, 2025 to June 30, 2028. The project aims to advance understanding of cancer biology and...
This $963,000 Project Grant award from the National Institute of Standards and Technology (NIST) under the Congressionally-Identified Projects program (CFDA 11.617) will fund the acquisition of four pieces of specialized research equipment at Nova Southeastern University in Fort Lauderdale, FL. The instruments, including a Seahorse XF24 and Oroboros Oxygraph 2K, a fluorescence microscope, a NanoString nCounter and prep station, and a CODEX digital spatial profiler, will be used to advance new...
This $427,095 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) supports the development of a novel microfluidic droplet-based platform (MDP) technology to generate and analyze a 3D biomimetic multicellular immunogenic tumor model. The goal is to establish multiple levels of hypoxia within the tumor-chip, investigate spatiotemporal interaction between the tumor microenvironment and cancer-immune cells during...
The National Cancer Institute (NCI) awarded a Project Grant (CFDA 93.393 - Cancer Cause and Prevention Research) in the amount of $425,772 to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. located in Tampa, Florida. The award, with a project period from July 15, 2024 to June 30, 2026, will support an epidemiologic study of microplastic pollution in bronchoalveolar lavage fluid and its association with lung cancer. As a National Cancer Institute-designated comprehensive...
This $568,538 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research at the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The project aims to understand how the release of the cytokine interleukin-1 alpha alters the immune response during cancer therapy, how this release is controlled by different cell death pathways activated by therapies, and if targeting interleukin-1 alpha can enhance response...
The U.S. Department of Defense's Defense Health Agency awarded a $481,749 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. (Moffitt Cancer Center) under the Military Medical Research and Development program (CFDA 12.420). The grant, effective September 30, 2023 through September 29, 2026, will support research to dissect the spatial molecular architecture of the transformed cutaneous T cell lymphoma tumor microenvironment, with the goal of identifying novel...
The National Institute of Standards and Technology (NIST) awarded a $2,800,000 Project Grant (CFDA 11.617 - Congressionally-Identified Projects) to the University of Mississippi Medical Center (UMMC) to fund the procurement of furnishings and equipment for the Translational Research Center (TRC) building on the UMMC campus in Jackson, MS. The project involves furnishing and equipping approximately 7,625 square feet of existing space for cancer research laboratories, support space, and...