Project Grant 2532545
- This federal Project Grant award for $358,371, provided by the National Science Foundation's Engineering program (CFDA 47.041), aims to develop a wireless bioelectronic system for high-performance fentanyl monitoring in the brains of freely moving small animal models. The key objectives are to: 1) isolate, characterize, and engineer aptamers targeting fentanyl; 2) develop an implantable nanoporous electrochemical aptamer-based (nanoeAB) fentanyl sensor and study a new surface coating to...
- The National Science Foundation (NSF) Division of Electrical, Communications and Cyber Systems awarded a $399,541 Project Grant to the Trustees of Dartmouth College to develop a high-throughput, label-free, and portable sensor that can quantitatively detect multiple illicit drugs including opioids, cocaine, psychostimulants, and methadone in liquid samples such as biofluids. The project aims to create a silver or gold nanoparticle-decorated zinc oxide nanorod coated silica nanofiber matrix...
- This federal Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $649,585 to Auburn University to develop an integrated and miniaturized opioid sensor system. The project aims to address the opioid crisis through innovative, cost-efficient, and portable opioid biosensors that can enable real-time, accurate detection and monitoring. The interdisciplinary team is working to deliver solutions for law...
- This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $540,458 to Louisiana Tech University to develop an advanced implantable neural interface device. The goal is to create a transformative technology capable of simultaneously monitoring multiple brain signals, including both chemical and electrical, over extended periods. By integrating innovative materials and fabrication techniques, the device aims to enhance signal detection...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to assess the impact of chronic, voluntary fentanyl intake on gene expression and neuronal activity in the brain. Specifically, the $139,927 award to the University of Washington will fund studies using single-cell RNA sequencing and whole-brain imaging in mice to investigate the molecular and circuit-level mechanisms underlying...
- The National Institute on Drug Abuse (NIDA), under the Federal Grant Program titled "Drug Use and Addiction Research Programs" (CFDA 93.279), awarded a $305,369 Project Grant to Taesun, LLC, a for-profit, woman-owned limited liability company based in Salida, Colorado. The award aims to develop a comprehensive device that integrates fentanyl test strips with sample preparation features, providing a more convenient and discreet method for fentanyl testing in high-risk environments....
- The National Science Foundation (NSF) awarded a Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Resilient Lifescience, Inc. for the development and validation of a novel wearable medical device to detect and treat opioid overdose. The $274,964 award, effective March 15, 2024 through December 31, 2024, will fund the development of two key components: 1) a self-contained, patch-based drug delivery platform capable of reliably delivering multiple...
- This Project Grant award, valued at $495,950.00, was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) with a start date of September 1, 2025 and an expected completion date of August 31, 2028. The award was granted to The Washington University in St. Louis, Missouri to investigate the mechanisms by which the mu opioid receptor (MOR) signaling within the nucleus of the solitary tract (NTS) mediates fentanyl-induced cardiorespiratory...
- This Project Grant award, titled "CAREER: An Artificial Nervous System for In-Body Communication Between Wearable and Implantable Devices", was provided by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041). The project aims to develop and optimize a communication platform that enables networking between wearable sensors and implantable therapeutic actuators throughout the body's tissue layers. Key objectives include optimizing an emitter-receiver...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $450,000.00 to the University of Texas at Austin over the period of January 1, 2025 to December 31, 2027. The project aims to develop novel biosensing tools for therapeutic drug monitoring, specifically for the antipsychotic medication clozapine. The key products and services to be delivered include: Selection and optimization of DNA/RNA aptamers that bind strongly and...
This federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $200,138 to North Carolina State University to develop a wireless bioelectronic system for high-performance fentanyl monitoring in the brain of freely moving small animal models. The key goals are to: 1) engineer aptamers targeting fentanyl, a primary opioid associated with opioid use disorder (OUD); 2) develop an implantable nanoporous electrochemical aptamer-based (nanoeAB) fentanyl sensor and study a new surface coating to improve its in vivo longevity; and 3) establish and validate a wireless bioelectronic system for fentanyl monitoring in the brain of freely moving subjects. This effort aims to provide urgently needed technologies to understand how opioids modulate diverse behavioral outputs of the brain with high spatiotemporal resolution, with broader applicability to biosensors for therapeutic drug monitoring, immune response tracking, and chronic disease management. The project will also engage high school and undergraduate students through training and the incorporation of new course modules at North Carolina State University and the University of Connecticut.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.1k | 8/5/25 |