Project Grant 2529541
- The National Science Foundation awarded a $399,685 project grant to the University of California Irvine under the Engineering program (CFDA 47.041) to develop innovative cartilage tissue engineering strategies utilizing the microgravity environment of the International Space Station. The objectives of the three-year award beginning September 1, 2022 include employing microgravity conditions to enhance key processes in earth-based cartilage tissue engineering such as redifferentiation of expanded...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports a collaborative research project to advance understanding of articular cartilage, the soft tissue covering the ends of bones in joints. The $420,000 award to Cornell University, spanning June 2025 to May 2028, will examine how cartilage responds to physical forces relevant to daily activities. The project aims to integrate theoretical modeling, simulations, and experiments to study how...
- This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
- This National Science Foundation (NSF) award under the Engineering program (CFDA 47.041) supports a collaborative research project to advance the understanding of articular cartilage, a living load-bearing tissue that can endure decades of mechanical stress. The $230,000 project, running from June 1, 2025 to May 31, 2028, will examine how cartilage responds to physical forces relevant to daily activities like walking and jumping, with a focus on understanding its response to shear forces...
- This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
- This three-year, $1.2 million project grant from the National Science Foundation's Engineering program (CFDA 47.041) will support research at Washington State University and Cornell University to develop new tissue engineering strategies for cartilage regeneration. The researchers aim to stimulate adult stem cells to become mature chondrocytes for cartilage production through small molecules that interfere with bone cell differentiation genes. Real-time imaging will monitor cell growth...
- This Project Grant award of $285,630 from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support research at the University of New England (UNE) to elucidate the molecular mechanisms by which articular chondrocytes (cartilage cells) respond to mechanical forces and regulate cartilage health. The goal is to advance the understanding of the pathogenesis of osteoarthritis, a leading cause of joint pain and disability. The research objectives include establishing...
- This Project Grant award, valued at $624,622.00, was made by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the University of Vermont & State Agricultural College (UVM) to support research on the relationship between the microscopic structure and macroscopic function of cartilage. The research project aims to improve the scientific understanding of cartilage and its role in osteoarthritis, a debilitating disease affecting 30 million adults in the United...
- This $382,124 federal Project Grant award, made by the National Science Foundation's Engineering program (CFDA 47.041), aims to advance tissue engineering and in-space cell technologies for regenerative medicine applications. The award will fund a collaborative effort between Micro-Grx, Inc., the University of Florida, Ronawk, and Redwire to develop three-dimensional "bio-block" tissue models that mimic the vascularization of heart and skin cells. These bio-block organoids will be used...
- This Project Grant award of $399,276.00 from the National Science Foundation's Engineering program (CFDA 47.041) will support research at the University of Puerto Rico to investigate how mechanical forces from growth substrate rigidity and microgravity affect the function and inflammatory response of mesenchymal stem cells (MSCs). The goal is to understand how physical cues influence the regenerative properties of MSCs, which is critical information for improving MSC-based therapies and...
This Project Grant award for $400,000 from the National Science Foundation's Engineering program (CFDA 47.041) supports the development of immunomodulatory cartilage tissue constructs by the University of Connecticut. The project aims to engineer "smart" cartilage tissue that can thrive in challenging environments, such as low-gravity conditions or under inflammatory stress. The research combines advanced nanomaterials with human mesenchymal stem cells to create cartilage constructs that actively regulate immune responses. Outcomes of this work could benefit both astronauts experiencing tissue degeneration during long-term space missions, as well as individuals on Earth requiring tissue-engineered cartilage. In addition to the scientific research, the project will provide training for undergraduate and graduate students and offer public outreach programs. The award period runs from October 1, 2025 to September 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.0k | 8/20/25 |