Project Grant 2514478
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program will fund the "Multicellularity Long Term Evolution Experiment (MULTEE)" to investigate the genetic, molecular, and physiological processes involved in the transition from single-celled to multicellular organisms. Totaling $596,940.00 and running from June 15, 2025 to May 31, 2030, the project will use the yeast Saccharomyces cerevisiae as a model system to...
- This Project Grant award of $133,324 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by Georgia Tech Research Corporation investigating the role of kin recognition in the evolution of multicellular organisms from unicellular ancestors. The research aims to identify the molecular mechanisms underlying kin recognition and test whether this ability enables the evolution of multicellular adaptations in the yeast Saccharomyces cerevisiae, a model...
- This National Science Foundation project grant award of $138,000 provides funding from November 1, 2022 through October 31, 2024 to support research and training under the Biological Sciences federal grant program (CFDA 47.074). The award will fund a postdoctoral fellowship to investigate how gene-environment interactions have shaped the repeated evolution of differentiated multicellularity. The fellow will employ single-cell transcriptomics and comparative analyses to examine how...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,199,995 Project Grant to The Washington University in St. Louis to characterize the genetic and epigenetic determinants of the transition from unicellular to multicellular states in the slime mold Dictyostelium discoideum. The project, funded through the Biological Sciences CFDA Program (47.074), leverages this organism's ability to regularly shift between unicellular and multicellular forms to...
- This Project Grant award of $270,000 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a postdoctoral research fellowship investigating the microbial ecology of an extremophile choanoflagellate. The research aims to shed light on how environmental forces shaped the evolutionary emergence of animals from unicellular ancestors. Specifically, the project will study Barroeca monosierra, a recently discovered multicellular choanoflagellate isolated from...
- This $298,375 Project Grant award from the National Science Foundation's Biological Sciences program supports a collaborative research project focused on understanding how populations evolve in complex, changing environments. The primary awardee, Virginia Tech, will conduct both experimental and theoretical work to investigate the relationships between an individual's environmental preferences, developmental processes, and patterns of phenotypic plasticity. The researchers aim to develop a...
- The National Science Foundation (NSF) awarded a $739,066 Project Grant to Duke University to examine how a model one-celled organism, Tetrahymena thermophila, adapts to changing temperatures. The funded research, part of NSF's Biological Sciences program (CFDA 47.074), aims to resolve critical gaps in understanding how rapid global climate change may affect the evolution of protist growth rates and respiration, with potential implications for both climate change and public health. The 5-year...
- This $303,254 Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), will fund research exploring the idea that the earliest adaptive evolution occurred through self-amplifying cycles of chemical reactions, rather than nucleic acids. Over a three-year period from August 2022 to July 2025, Michigan State University will conduct theoretical and laboratory studies to analyze how mixtures of chemicals could...
- This Project Grant award, funded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports research at Brown University to investigate the evolutionary mechanisms underlying the diversity of life on Earth. The research focuses on analyzing changes in the developmental programs of echinoderms, such as sea urchins and sea stars, to understand how unique cell types like micromeres evolved and their potential role in species divergence. The $1,337,703 award...
- This $262,588 National Science Foundation Project Grant under the Geosciences program (CFDA 47.050) will support research into prebiotic chemistry processes relevant to the origin of life on Earth. The Foundation For Applied Molecular Evolution, Inc. will use the funding to advance scientific understanding of geological environments on Earth 4.35 billion years ago that could have facilitated the emergence of the first genetic molecules. Key deliverables include completing structural analysis...
This National Science Foundation (NSF) Project Grant award for $584,898, titled "BEYOND SIZE LIMITS: EXAMINING THE BIOPHYSICAL BASIS OF MULTICELLULAR ADAPTATION", is being provided to the Georgia Tech Research Corporation to conduct fundamental research on the evolution of multicellular life forms from single-celled organisms. The research leverages a long-term laboratory evolution experiment using engineered yeast to directly observe the process of multicellularity evolving in real-time over thousands of generations. Key objectives include studying how the evolved "snowflake yeast" have grown from microscopic clusters to centimeter-sized organisms, while developing remarkable abilities like self-generated fluid flows, wound healing, and complex nutrient transport structures. By combining biophysics, evolutionary biology, and computational modeling, this project aims to reveal the underlying physical principles driving the evolution of increasingly complex life forms. The award also includes an educational component providing research opportunities to high school and undergraduate students to help train the next generation of scientists in this critical research area. This work has significant implications for understanding the origins of complex life on Earth, from plants and animals to humans.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $584.9k | 8/18/25 |