Project Grant 2507508
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences Program (CFDA 47.049) provides $525,000 to East Carolina University (ECU) to study the functional and structural properties of enzymes involved in persulfide degradation. Specifically, Professor Holly Ellis and her research team at ECU will examine the catalytic mechanism and structural features of a mercaptopropionate dioxygenase (MDO) and a sulfurtransferase (ST) enzyme system that is critical...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to the University of California, Berkeley provides $780,000 in funding to investigate the molecular mechanisms of oxygen-dependent enzymes and develop synthetic mimics. The key objectives are to study a class of oxygen-dependent decarboxylase enzymes that utilize iron, manganese, or mixed metal active sites. This research aims to elucidate the critical oxygen-activated...
- The National Science Foundation (NSF) awarded a $405,960 Project Grant to Rensselaer Polytechnic Institute (RPI) under the Mathematical and Physical Sciences program (CFDA 47.049) to investigate enzymes from organisms living in deep sea environments. The research aims to understand how these enzymes, known as extracellular deoxyribonucleases (exDNases), have adapted to function under the extreme conditions of high pressure and temperature in the deep ocean biosphere. The work will combine...
- The University of North Carolina at Chapel Hill will receive $495,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to support research into designing artificial enzymes from June 2022 to May 2025. Dr. Albert Bowers and his team will develop a generalizable strategy for separating substrate binding and catalysis functions into distinct domains for peptide-based enzymes. They will use computational protein design with Rosetta to create...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
- This $240,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund a postdoctoral research fellowship focused on discovering and functionally exploring nature's repurposed enzymes in specialized metabolism. The research aims to identify and characterize new enzymes that have gained novel functions through evolutionary changes, with the potential to discover useful tools for biotechnology and medicine. The fellowship will support a...
- The National Science Foundation (NSF) awarded a $479,856 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of Kansas Center for Research Inc. The grant, awarded on September 1, 2025 with an ultimate completion date of August 31, 2028, supports the development of new manganese and iron complexes that mimic intermediates in biological metal-dependent enzymes. The goal is to use these complexes to improve proton-coupled electron-transfer reactions,...
- This NSF-funded Project Grant, titled "Structural and Biophysical Analysis of Evolved Fe(II)/2-Ketoglutarate-Dependent Azidases to Understand and Expand the Substrate Scope of Enzymatic C-H Functionalization," is awarded by the National Science Foundation's (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041). The $494,253 grant, awarded to the Trustees of Indiana University, aims to develop an engineered enzyme...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $645,000 to North Carolina State University to study the structures and functions of a newly discovered class of enzymes called heme oxygenase-like dimetal oxidases/oxygenases (HDOs). The goal is to determine how structurally similar HDO proteins can catalyze radically different chemical transformations. The research will leverage bioinformatics, structural, and mechanistic enzymology to create a publicly available online database (HDOBASE) to facilitate HDO discovery. The project aims to elucidate the structural and mechanistic principles that allow HDOs to catalyze diverse reactions, with a focus on understanding the role of the secondary coordination sphere, substrate positioning, and substrate type in tuning HDO reactivity. No sub-awards are planned under this grant, which has an award date of September 1, 2025 and a planned completion date of August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $645.0k | 8/27/25 |