Project Grant 2506679
- This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and vaccines....
- The National Science Foundation (NSF) awarded a $1,250,000 Cooperative Agreement under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Rattan Life Science Inc., a small disadvantaged business, to develop a novel platform technology for the scalable generation of high-quality, tumor-targeted induced naïve T cells for off-the-shelf cancer immunotherapies. The project aims to demonstrate the in vivo anti-tumor efficacy of these induced naïve T cells targeting CD19 for...
- This Project Grant award, provided by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a microchip-based technology for advanced cell engineering. The $305,000 award to Cellecho, Inc., with a project period from April 2025 to March 2026, will fund the design and optimization of a miniaturized instrument that leverages sound waves and electric fields to manipulate cells and deliver genetic materials. This innovation...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
- This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
- This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $305,000 to Bullseye Biodevices, Inc. to develop a novel biosensing device for rapidly mapping volumetric tumor margins. The objective is to create an electromechanical probe and sensor system that can generate a real-time, three-dimensional map of tumors during surgical interventions. This technology aims to enhance tumor removal accuracy,...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $250,000 to Old Dominion University Research Foundation (Odurf) to develop low-cost, mRNA-based manufacturing technologies for chimeric antigen receptor T-cells (CAR T-cells). The objective is to address safety and cost barriers to wider adoption of CAR T-cell therapies, which are an important class of cell-based cancer treatments. The research will investigate how external mRNA molecules...
- Rattan Life Science Inc. received a $275,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a platform for generating induced pluripotent stem cell-derived naïve CD4+ and CD8+ T cells with fidelity, reproducibility and scalability. The platform employs proprietary induced thymic epithelial cells to provide biologically relevant thymic positive selection signals during T cell differentiation,...
- This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...
This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $304,870 to Toro Bio, Inc. to develop an automated system for point-of-care manufacturing of tumor infiltrating lymphocyte cell therapies. The project aims to expand access to personalized cancer treatments by enabling decentralized cell therapy production, which could improve patient outcomes, reduce treatment costs, and support a more resilient healthcare system. The key technical goals are to manufacture and test alpha prototypes of a disposable bioreactor system, develop bioreactor nests for parallelization and scalability, and validate the complete alpha system with real cell cultures. This innovation seeks to reduce cleanroom dependency and manual labor in cell therapy manufacturing.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $304.9k | 9/4/25 |