Project Grant 2451973
- This $245,723 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will support collaborative research at Iowa State University of Science and Technology to develop a mathematical theory for the biological concept of modularity. The project aims to define modular structures in biological systems in a mathematically rigorous way, determine the advantages of modularity for organisms, and leverage modularity to advance the...
- This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
- This National Science Foundation (NSF) Project Grant award, under the Biological Sciences program (CFDA 47.074), provides $246,762 to the University of California Irvine (UC Irvine) from April 1, 2024 to March 31, 2026. The project aims to develop a deeper understanding of the principles governing how biological organisms build robust and precise traits from variable and unreliable components, and how these insights can be applied to improve the resilience of engineered systems. Key focus...
- This $1,999,998 National Science Foundation Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports research at the University of Washington to advance plant synthetic biology through deciphering the grammar of crop gene regulatory elements. The three-year award beginning March 1, 2023 will apply massively parallel reporter assays and machine learning to characterize tens of thousands of genetic regulatory elements in maize and tomato, including enhancers,...
- Iowa State University of Science and Technology (ISU) was awarded a $796,021 Project Grant from the National Science Foundation on February 15, 2021 to complete work by January 31, 2024. The grant supports ISU's project "Regulatory Networks that Control Autophagy to Enable Environmental Stress Resilience in Plants" under the Biological Sciences program (CFDA 47.074). The project aims to increase scientific understanding of major problems confronting the nation by promoting progress...
- This Project Grant award of $520,720 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support research to develop new tools for incorporating emerging models of genetics into genetic mapping, prediction, and simulation. The research, conducted by Colorado State University, aims to better integrate molecular and cellular biology knowledge into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype...
- This $735,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support research at Cornell University to investigate the interactions of plant transcription factors that regulate the three-dimensional patterning of grass leaves. The research aims to gain a better understanding of the functional interactions between the LIG1 and WOX3 transcription factor genes, which are critical for determining leaf width, length, and angle in grasses like...
- This $959,997 federal Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), supports collaborative research at the Cold Spring Harbor Laboratory to develop improved methods for plant transformation and regeneration. The research aims to provide a thorough understanding of the molecular mechanisms underlying regeneration in maize, a key crop that provides a substantial portion of human caloric intake. By exploiting a "morphogenic-based"...
- This National Science Foundation (NSF) Project Grant, awarded under the Integrative Activities program (CFDA 47.083), will support collaborative research at Kansas State University to identify the genetic basis of plant regeneration, specifically focusing on maize. The $400,000 award will fund the project from September 1, 2023 to August 31, 2027. The primary goal is to better understand the genetic mechanisms controlling plant cell proliferation and growth, which are critical for successful...
- This $5 million National Science Foundation Project Grant, awarded under the Biological Sciences program (CFDA 47.074), funds research and educational activities related to leaf angle variation in maize plants from 2022-2026. Iowa State University will lead efforts to identify genes controlling leaf angle variation across plant canopies using high-throughput phenotyping and transcriptomic analyses. Functional validation of candidate genes will be conducted through CRISPR-based gene editing....
This Project Grant award of $487,608.00 from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research on the design principles and canalization of gene regulatory network (GRN) models. The project, conducted by Iowa State University of Science and Technology, aims to elucidate how GRNs in all living organisms achieve stability and resilience through their structural properties, even in the face of environmental changes or genetic mutations. Using computational modeling and analysis of expert-curated GRN data, the researchers will uncover fundamental design principles that enable this biological robustness. The findings will be validated through experiments on the model plant species Arabidopsis. The broader impacts include developing public databases and software tools to aid scientists in understanding genetic systems, as well as contributing to the interdisciplinary training of STEM workforce. The award period is from September 15, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $487.6k | 7/31/25 |