This $477,088 CAREER award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to the Icahn School of Medicine at Mount Sinai (ISMMS) aims to develop a miniature sensor capable of measuring how heat flow within living cells is affected by variations in thermal conductivity. The research project seeks to investigate the relationship between localized thermal conductivity and cellular functions such as metabolism, enzyme dynamics, and signal transduction pathways. The project involves the design, fabrication, and calibration of a biosensor to achieve precise measurements of thermal conductivity, with experimental studies focused on various cell models. The findings are expected to advance the understanding of cellular thermodynamics and contribute to the development of diagnostic tools and therapeutic interventions, particularly in areas like cancer therapy and the study of metabolic disorders and neurodegenerative diseases. No sub-awards are planned for this project.
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