This NSF/FDA SIR Project Grant award of $199,930 to the University of Chicago aims to develop a molecule-based sensor that can quantify the mechanical stresses induced by microbubbles during therapeutic ultrasound procedures. The goal is to provide the FDA with data and a regulatory tissue phantom to better assess the safety and effectiveness of focused ultrasound devices that use microbubbles to non-invasively treat cancers. The project will establish the link between microbubble-induced stresses, cell death, and other markers of therapeutic ultrasound efficacy. Educational materials for high school physics classes will also be developed to disseminate the research findings. This award is funded through the NSF Engineering program (CFDA 47.041), which supports fundamental engineering research and innovation across diverse technical domains.
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