The National Science Foundation (NSF) Division of Chemistry awarded a $624,973 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to Stanford University for the research project "PROBING AND DESIGNING CASCADE REACTIVITY IN CONSECUTIVE MECHANOACTIVATION OF COVALENT BONDS". This 3-year grant will support experimental and computational investigations by Professors Yan Xia and Todd Martinez into understanding force-driven reaction pathways and cascade reactivity in responsive molecular systems, known as mechanophores. The proposed research aims to elucidate the kinetic energy transduction, non-statistical dynamic effects, and cascade reactivity occurring in consecutive mechanoactivation events across coupled mechanophores. This work will advance fundamental knowledge in physical organic, polymer, and computational chemistry, while also providing educational opportunities for students, including those underrepresented in science. No sub-awards are planned under this grant.
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