The National Science Foundation (NSF) awarded a $498,000 Project Grant under its Mathematical and Physical Sciences (MPS) program to The Research Foundation for the State University of New York (RF SUNY) for the development of cell-penetrating monobodies. The 3-year project, beginning March 2024, will explore innovative approaches to engineer monobodies - antibody-like proteins - with enhanced cell permeability for potential therapeutic applications. Key objectives include using computational deep learning and bacterial surface display techniques to reinforce monobody structure and endow cell-penetrating capabilities. This research aims to optimize monobody scaffolds for designing selective inhibitors targeting oncogenic proteins within cells. The project will also provide multidisciplinary research opportunities for underrepresented undergraduate students at SUNY Buffalo through collaborations with its minority-focused programs. No subawards are planned under this grant.
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