The University of Florida (UF), through its Division of Sponsored Research, has been awarded a $256,832 Project Grant from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to develop new catalysts capable of selectively cleaving specific amide bonds in complex peptide structures. The research team led by Dr. Masayuki Wasa aims to mimic the spatial differentiation and catalytic efficiency of natural protease enzymes to achieve site-specific peptide functionalization - a critical capability for the synthesis and analysis of complex peptide-based natural products. This project will also provide training opportunities for graduate, undergraduate, and high school students in the chemical sciences. The award commenced on July 1, 2023 and is expected to conclude by August 31, 2024. No sub-awards are planned under this grant.
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