Project Grant 2341058
- This $388,983 federal Project Grant award from the National Science Foundation (NSF) Division of Chemistry's Chemical Measurement & Imaging Program and Chemistry of Life Processes Program supports the development of a new optical microscope by Professor Eric Potma at the University of California, Irvine. The instrument leverages chiral sum-frequency generation (SFG) microscopy to visualize protein structures in cells and tissues without the need for chemical labeling. This label-free imaging...
- This $475,670 CAREER Project Grant awarded by the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) aims to develop a new method for tracking molecular changes in live tissue over time. The project will focus on creating a nanostructure-based system to continuously monitor cellular activity and interactions, which can help improve understanding of cellular behavior and advance medical treatments, particularly for complex...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
- The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
- This $546,494 award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) will enable the University of California, Irvine (UCI) to acquire a high-resolution optical photothermal infrared (OPTIR) microscope system. This new microscope will support cutting-edge scientific research programs at UCI, foster collaborations with California State University Fullerton, and accelerate partnerships with industry. The OPTIR microscope will allow for sensitive,...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $730,000 to the University of California, Los Angeles (UCLA) aims to transform the field of protein engineering through the development of an innovative technology called PicnnnShells. PicnnnShells are tiny, hollow particles that can rapidly screen up to one million different protein variations in a single day to identify useful proteins for research, industrial or medical applications. The...
- This $526,873 federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the University of California, Riverside on the mechanisms of protein-protein associations facilitated by molecular "glues". The research aims to computationally model and experimentally investigate how these molecular glues mediate the formation of protein complexes and enhance their biological functions. The project will contribute to...
- This $995,498 National Science Foundation project grant supports research at the University of California, Los Angeles to advance knowledge of cellular mechanobiology and translate findings for sustainable protein production. Funded through the NSF's Engineering program (CFDA 47.041), the research aims to understand how cells sense and respond to mechanical stimuli by building a systems-level understanding of the "mechanome." Specific goals include investigating predicted mechanical...
- The National Science Foundation (NSF) awarded a $630,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of New Mexico (UNM) to develop an advanced optical microscopy system. The project aims to significantly improve the study of protein clustering and interactions on cell membranes, which could advance the understanding of cell signaling and related diseases like cancer. The highly interdisciplinary research will combine the MINFLUX and modal...
- The University of California, San Diego (UCSD) was awarded a $587,425 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to develop the first dual-modality super-resolution microscopy system, termed Dual-Modality Localized Plasmonic Structured Illumination Microscopy (DM-LPSIM). This new imaging technology will enable simultaneous high-speed super-resolution fluorescence and label-free scattering imaging at the 50-nanometer scale. The DM-LPSIM system...
This $531,227 CAREER award from the National Science Foundation's (NSF) Engineering program to the University of California, Irvine (UC Irvine) aims to develop a new "OptOGel Proteomics" technique for high-resolution analysis of subcellular protein localization and function. The project will focus initial validation on mapping the nuclear lamina, a cellular structure implicated in cancer and aging. The research seeks to overcome limitations of current spatial proteomics tools by combining expansion microscopy, photoreactions, and multi-photon microscopy to isolate and analyze proteins within precise subcellular locations. Broader impacts include disseminating the new OptOGel Proteomics and Label-Retention Expansion Microscopy methods to enhance life sciences research capacity, as well as conducting annual workshops and promoting gender equity in science. The 5-year project period runs from July 2024 through June 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $531.2k | 1/25/24 |