The Regents of the University of Minnesota received a $160,000 Project Grant award from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support the METALLA-NHCS project from October 1, 2022 through September 30, 2023. Under the direction of Professor Ian Tonks, the University of Minnesota will design and synthesize new metal-based carbene ligands called metallanhcs that can be used to develop switchable...
This three-year, $524,083 National Science Foundation project grant funds research into understanding the mechanism of C-X hydrogenolysis catalyzed by supported metal nanoparticles. Professors from Barnard College, the University of Maine, and the University of Houston will study how to catalytically reduce carbon-halogen bonds found in pesticides and other molecules. The collaborative team will use experimental and computational approaches to learn how to selectively remove halogens and study...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) provides $600,000 to the University of Rochester to study anomalous versions of well-understood chemical reactions. The 3-year project (7/1/2025 - 6/30/2028) will focus on exploring the boundaries between electrocyclic and ionic reactivity, developing higher-order cationic electrocyclizations, and investigating nonlinear polyene cyclizations to synthesize complex...
Professor Steven Rokita of Johns Hopkins University was awarded a $510,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to develop new biocatalysts through cofactor engineering. The three-year award running from July 2022 to June 2025 will support research using organic synthesis to create novel cofactors that, paired with protein scaffolds, could enable applications in green chemistry and bioremediation. By modifying cofactors...
This $555,000 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry and Molecular and Cellular Biosciences Division is supporting biophysical studies of metalloenzymes conducted by Professor Brian Hoffman at Northwestern University. The research focuses on investigating the structure and function of multimetallic metalloenzymes, particularly those with Fe4 clusters and Fe3M (M=Fe, Mo) analogues, as well as the active site cofactors of nitrogenase...
This National Science Foundation (NSF) Division of Chemistry award provides $760,000 over 4 years to support an interdisciplinary research project led by Professors Colin Nuckolls and Xavier Roy of Columbia University. The project aims to explore the development of a new class of macromolecular materials that combine electronic and chiral properties, with the goal of understanding how chirality can be used to control spin-selective electron transport. This research will integrate advanced design...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $388,369 Project Grant to the Regents of the University of Minnesota to support research extending the catalytic activity of enzymes to unnatural reactions from May 15, 2021 through April 30, 2024. Under the grant, the University of Minnesota will conduct research exploring how to engineer enzymes to catalyze reactions not found in nature, with the goal of expanding the...
The National Science Foundation's (NSF) Division of Chemistry awarded a 5-year, $799,246 CAREER grant to Dr. Colin Kinz-Thompson at Rutgers University-Newark to investigate the mechanistic roles of receptor oligomerization in molecular signaling. The proposed research aims to experimentally determine how accurately bacterial receptors can sense small molecules and whether this sensing process can be reprogrammed for new applications like improved monitoring and diagnostics in agriculture or...
This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Emory University to develop practical methods for conducting synthetic organic transformations using low catalyst loadings. The goal is to create highly efficient catalysts, such as rhodium and ruthenium-based catalysts, that can be used in extremely low amounts to enable over 100,000 reaction cycles while...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....