Project Grant 2333907
- This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
- The National Science Foundation (NSF) awarded a $280,990 Project Grant through its Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Los Angeles (UCLA) to investigate the factors governing the activity of nickel-containing metalloenzymes. The research, led by Professor Hannah Shafaat, aims to elucidate the mechanisms of biological hydrogen conversion processes using model metalloenzymes. Key objectives include obtaining detailed spectroscopic data on...
- This $208,879 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between Marquette University and the Colorado School of Mines to gain molecular-level insights into the catalytic mechanism of nitrile hydratase enzymes. Professors Bennett, Fiedler, and Holz will employ kinetic, spectroscopic, biochemical, computational, and X-ray crystallographic methods to detect intermediates, test competing mechanistic...
- This $600,000 Project Grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at Northwestern University to develop new atom-efficient catalytic transformations using earth-abundant metals. Professor Tobin Marks and his research group will discover, understand, and optimize f-element and d(0)-transition metal catalysts for three types of critical organic reactions, with the goal of making catalytic...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), awarded The Administrators of Tulane Educational Fund (Tulane University) a $284,240 Project Grant to study synthetic molecules relevant to the Earth's nitrogen cycle. The 5-year research project, which began on June 1, 2025, aims to prepare and investigate new terminal hydride complexes of manganese and iron, particularly those with electron counts pertinent to the...
- This $398,196 federal Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) funds a collaborative research project between the United States and Germany to investigate the initial steps involved in the synthesis of metallocofactors for the nitrogenase enzyme. The project aims to elucidate how the NifU and NifS proteins in the model bacterium Azotobacter vinelandii assemble the iron-sulfur building blocks required for nitrogenase...
- The National Science Foundation (NSF) awarded a $197,237 Project Grant to the University of Missouri System, doing business as Missouri University of Science & Technology (Missouri S&T), through the Mathematical and Physical Sciences (MPS) program. The grant is being used by Professor Shelley Minteer at the University of Utah to develop new electroanalytical tools for investigating enzymes, which are critical biological catalysts with applications in biotechnology and catalysis. Key...
- This $1,500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at Northwestern University to develop innovative protein-based biomaterials. The research aims to (1) engineer mussel foot proteins with superior underwater adhesive properties compared to wild-type sequences, and (2) create resilin-inspired bioelastomers with high strength while retaining natural mechanical resilience. The proposed...
- This $600,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at the University of Michigan and Trinity University to investigate the structural and electronic properties of high-valent cobalt, nickel, and copper-oxo complexes. The project aims to improve understanding of how metal-oxo versus metal-oxyl character impacts the stability and reactivity of these unstable, yet potentially useful,...
This $555,000 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry and Molecular and Cellular Biosciences Division is supporting biophysical studies of metalloenzymes conducted by Professor Brian Hoffman at Northwestern University. The research focuses on investigating the structure and function of multimetallic metalloenzymes, particularly those with Fe4 clusters and Fe3M (M=Fe, Mo) analogues, as well as the active site cofactors of nitrogenase isozymes. Advanced paramagnetic resonance techniques are being used to characterize the "organometallic" states of these enzyme active sites and understand their role in catalytic mechanisms. The project aims to enhance understanding of terpenoid biosynthesis, radical-SAM enzymes, and the critical nitrogen fixation process catalyzed by nitrogenase. This work will contribute to the scientific knowledge base, train the next generation of scientists, and broaden participation in STEM fields.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $555.0k | 3/18/24 |