This $250,000 Project Grant awarded by the National Science Foundation's (NSF) Office of International Science and Engineering (CFDA 47.079) supports the development of a Global Center on Climate Change and Clean Energy with Southeast Asia as a living lab. The project, led by the University of Illinois, assembles a team of U.S. and Southeast Asian researchers to assess climate risks, evaluate impacts, and design adaptation and mitigation strategies to build resilience for vulnerable coastal communities in the region. Key activities include a workshop in Hanoi, three exploratory projects, and the development of a design plan for a future center-scale collaboration. The goal is to transform the education of engineers, computer scientists, biologists, and social scientists through an integrated approach to better prepare for climate-related disasters and mitigate disruptions to the global supply chain. Lessons learned will be valuable for other vulnerable coastal regions globally.