Purdue University will receive $345,209 from the National Science Foundation under the Mathematical and Physical Sciences program (CFDA 47.049) to develop electrochemical methods for detecting and quantifying single enzyme molecules. Professor Jeffrey E. Dick at the University of North Carolina at Chapel Hill will advance techniques to characterize chemical reactions catalyzed by individual enzymes using tiny electrodes within volumes smaller than a single cell. This has the potential to offer new insights into biochemical processes and support development of ultrasensitive biosensors. Students will gain training in electrochemistry and biotechnology. Outreach efforts will also create electrochemical instruments for high school science classes. Work will be completed by February 2024 to rigorously evaluate single enzymes' properties using novel measurement methods, including for rapid detection of individual virus particles.
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