The National Science Foundation's (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $274,975 Project Grant to Worcester Polytechnic Institute (WPI) under the NSF Engineering program (CFDA 47.041) to investigate the role of microbubbles in improving the efficacy of high-intensity focused ultrasound (HIFU) therapy.
The key objectives are to develop a well-controlled in vitro experimental setup to study temperature elevation in tissue phantoms with and without microbubbles under HIFU, and to validate a computational model to predict microbubble-assisted HIFU-induced temperature rise. WPI is collaborating with the University of Washington Bioengineering/Averkiou Lab as a sub-awardee to perform experiments for this project. The proposed research aims to advance HIFU therapy for cancer treatment by better characterizing the acoustic and thermal effects of microbubbles, enabling researchers to explore and optimize HIFU treatment parameters.
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