Project Grant 2301606
- This federal Project Grant award from the National Science Foundation (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $396,000 to Professor George L. Barnes of Illinois State University to investigate the reaction dynamics of collision-induced dissociation (CID) of post-translationally modified peptides and nucleosides using sophisticated simulation techniques. The research aims to elucidate CID reaction dynamics relevant to tandem mass spectrometry, develop a...
- This is a Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The $1,200,000 award aims to enable confident identification of challenging classes of peptides for which current mass spectrometry (MS) methods fail or produce unreliable results. The project will develop new computational tools for two-dimensional mass spectrometry (2D-MS), which introduces fragment-fragment correlation (FFC) to dramatically improve the...
- This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $343,638 to Texas A&M University-Commerce to conduct research on the thermochemistry, reaction dynamics, and conformational changes associated with the collisional activation of peptide ternary complexes and recombinant tagged proteins. The key products and services to be delivered through this 3-year grant include: Developing new zinc- and nickel-binding...
- The National Science Foundation Division of Chemistry awarded a $1,010,000 project grant to the University of Texas at Austin to develop innovative mass spectrometry methods for characterizing intact proteins through June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Jenny Brodbelt and her research group will apply ultraviolet photodissociation and other dynamic ion manipulation strategies to amplify structural and post-translational modification details...
- The National Science Foundation (NSF) awarded a $348,398 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program to Steffen Lindert and his group at Ohio State University. The funding will support computational studies to improve the understanding and outcomes of covalent labeling mass spectrometry (MS) measurements. The research aims to: 1) perform molecular dynamics simulations to understand how covalent labeling reagents interact with proteins and...
- This National Science Foundation Project Grant of $249,990 will support research into innovative structural characterization of biomolecular ions through mass spectrometry and infrared action spectroscopy. Funded under the Mathematical and Physical Sciences program (CFDA 47.049), Professor Daniel Thomas and students at the University of Rhode Island will study peptide and RNA chain folding properties by cooling samples in helium nanodroplets and analyzing infrared light absorption. Outreach...
- The National Science Foundation awarded a $599,940 Project Grant to the University of Chicago under the Mathematical and Physical Sciences program (CFDA 47.049) for research titled "COLLABORATIVE RESEARCH: DMREF: GOALI: HIGH-AFFINITY SUPRAMOLECULAR PEPTIDE MATERIALS FOR SELECTIVE CAPTURE AND RECOVERY OF PROTEINS." The four-year award beginning October 1, 2021 will support the development of new high-affinity supramolecular peptide materials for selective capture and recovery of...
- This $390,000 National Science Foundation Project Grant, awarded under the Mathematical and Physical Sciences program (CFDA 47.049), will support the development of Absolute Quantitative Protein Footprinting Mass Spectrometry (AQPFMS) for probing protein three-dimensional structures. Professor Hao Chen of the New Jersey Institute of Technology and collaborator Xiaolin Cheng of Ohio State University will refine an approach using AQPFMS to provide quantitative analysis of solvent-accessible...
- This federal Project Grant award, valued at $476,385.00 and funded by the National Science Foundation's (NSF) Division of Chemistry, supports a collaborative research project between Professor Michael Marty's team at the University of Arizona and industrial partners at Genentech, Inc. The project aims to develop new computational algorithms and experimental methods for improved analysis of complex mass spectrometry data, particularly focused on enabling more widespread use of intact mass...
- The University of Utah will use a $550,000 Project Grant from the National Science Foundation Division of Chemistry to examine thermochemistry of metal-ligand bonds and protonated peptides from June 15, 2023 to May 31, 2026. The work falls under the NSF Mathematical and Physical Sciences program (CFDA 47.049), which aims to advance scientific knowledge and understanding in these fields. Professor Peter B. Armentrout and his research group will utilize guided ion beam tandem mass spectrometry...
This National Science Foundation project grant of $120,813 awarded on November 1, 2022 supports research into the effects of post-translational modifications on peptide fragmentation patterns observed during tandem mass spectrometry experiments. The grantee, Illinois State University, will examine model systems relevant to MS2 under the guidance of Professor George Barnes. A combined computational and experimental approach will investigate how secondary structure and non-covalent interactions influence soft landing and collision-induced dissociation of protonated peptides and their post-translationally modified variants. Direct dynamics simulations, ab initio calculations, and experimental tandem mass spectrometry performed by undergraduate researchers will provide new fundamental insights into gas phase molecular collisions and reactions. This work under the Mathematical and Physical Sciences program (CFDA 47.049) aims to advance understanding of mass spectrometry and biomolecular analysis with implications for broader biological and health sciences. Collaboration with Professor Julia Laskin at Purdue University expands training opportunities for students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.8k | 10/21/22 |