Project Grant 2232550
- This National Science Foundation (NSF) Cooperative Agreement award, provided through the NSF Technology, Innovation, and Partnerships (CFDA #47.084) program, funds the development of a novel, fully implantable craniofacial distraction system by Ostiio LLC, a medical device company based in Philadelphia, PA. The $1,000,000 award aims to produce a magnetic, subcutaneous distraction device capable of gradually correcting skeletal abnormalities affecting craniomaxillofacial functions such as...
- The National Science Foundation (NSF) awarded a $273,563 Small Business Innovation Research (SBIR) Phase I grant to Medicarbone Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The objective of this 12-month project is to design, develop, and demonstrate the feasibility of a minimally-invasive intramedullary (IM) sleeve system with an in situ, photocurable, and removable polymeric bone cement for the treatment of orthopedic fractures. The project aims to address...
- The National Science Foundation Division of Industrial Innovation awarded a $256,000 Project Grant to develop an automatic debridement device from August 1, 2021 through March 31, 2022. This Small Business Innovation Research Phase I award under the Engineering (47.041) program will support the creation of a product to automatically remove dead, damaged, or infected tissue. The NSF Directorate for Engineering seeks to foster innovation and excellence in engineering research, consistent with...
- Sentire Medical Systems, Inc. was awarded a $256,000 National Science Foundation Project Grant to develop an intraoperative monitoring device to detect bowel injuries during laparoscopic surgical procedures. The goal of the NSF Technology, Innovation, and Partnerships program is to advance science and engineering research leading to breakthrough technologies that address national challenges. Through this award, Sentire Medical will characterize gases present during laparoscopic surgery to...
- This $274,547 Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a novel Aneurysm Sealing Device (ASD) for endovascular treatment of Abdominal Aortic Aneurysms (AAA). The project seeks to create a device that can completely seal the aneurysm sac, reducing the risk of post-procedure complications and the need for repeat interventions. Key objectives include validating the device's adaptability...
- This STTR Phase I Project Grant, awarded by the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program), provides $305,000 to Magsorbeo Biomedical Corp to develop a bioabsorbable magnesium alloy for maxillofacial fixation implants. The goal is to create a magnesium-based implant that can temporarily support healing, then gradually be absorbed by the body, eliminating the need for secondary removal surgeries. This innovation aims to improve healthcare...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award to Reselute, Inc. provides $998,921 to develop a novel implantable orthopedic medical device and procedure to reduce recovery duration and infection risks associated with severe traumatic fractures of the long bones. The project aims to advance a 3D-printed, antibiotic-releasing intramedullary nail to improve upon current standard-of-care implants that are prone to...
- This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on the development of a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by reducing or eliminating them through the use of this biocompatible and antimicrobial nano-biological coating. The $305,000...
- This $999,783 Phase II Small Business Innovation Research (SBIR) cooperative agreement from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports Intact Therapeutics' development of a thermogel-based drug delivery platform for the treatment of upper gastrointestinal bleeding (UGIB). Intact Therapeutics' proprietary thermogel technology aims to rapidly stop UGIB prior to endoscopic treatment, potentially reducing patient morbidity,...
- Nostopharma LLC was awarded a $256,000 Small Business Technology Transfer Phase I Project Grant from the National Science Foundation to develop a sustained-release, biodegradable nanoparticle drug delivery system for treatment of soft tissue trauma complications. Funded under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the 12-month project beginning March 1, 2022 aims to demonstrate in vitro and in vivo feasibility of modulating the ectopic bone microenvironment...
SBIR PHASE II: ENDOLUMINAL FIXATION OF A DISTRACTION ENTEROGENESIS DEVICE -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT IS THE ADVANCEMENT OF AN INNOVATIVE THERAPY FOR SHORT BOWEL SYNDROME. COMPARED TO CURRENT NON-CURATIVE TREATMENTS THAT ARE CHRONIC AND ASSOCIATED WITH DANGEROUS COMPLICATIONS, REHOSPITALIZATION, AND HIGH MORTALITY, THE PROPOSED SOLUTION HAS THE POTENTIAL TO SUBSTANTIALLY IMPROVE OUTCOMES AND QUALITY-OF-LIFE FOR PATIENTS AND THEIR FAMILIES. THE POTENTIAL COMMERCIAL IMPACT OF THIS PROJECT IS LIKEWISE SUBSTANTIAL. TREATING SHORT BOWEL SYNDROME CURRENTLY COSTS HUNDREDS OF THOUSANDS OF DOLLARS PER PATIENT PER YEAR. ADDS MORE THAN $5 BILLION TO US HEALTHCARE EXPENDITURES ANNUALLY. THUS, THE PROPOSED CURATIVE SOLUTION CAN LEAD TO ENORMOUS SAVINGS IN DOLLARS AND IN SPECIALISTS? TIME. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT WILL CREATE A CURATIVE THERAPY FOR PATIENTS WITH SHORT BOWEL SYNDROME, WHICH IS CURRENTLY MANAGED WITH INTRAVENOUS NUTRITION AND LACKS EFFECTIVE TREATMENTS. THE PROPOSED SOLUTION WILL LENGTHEN THE INTESTINE, INCREASING THE ABSORPTIVE SURFACE AREA AND RESTORING THE NATURAL FUNCTION OF THE GUT, ENABLING PATIENTS TO GET SUFFICIENT NUTRITION FROM THE FOOD THEY EAT. THE PROPOSED SYSTEM COMPRISES NONDESTRUCTIVE TISSUE ANCHORS AND A SPRING THAT PUSHES AGAINST THEM TO STRETCH THE INTESTINE AND FORCE IT TO GROW. HAVING PREVIOUSLY DEVELOPED THE TISSUE ANCHORS, THIS PROJECT DEVELOPS A DELIVERY METHOD THAT WILL ALLOW THE SYSTEM TO BE IMPLANTED IN THE INTESTINE THROUGH A MINIMALLY INVASIVE PROCEDURE. FEEDBACK WILL BE GATHERED FROM PEDIATRIC GASTROENTEROLOGISTS AND SURGEONS ABOUT THE DELIVERY METHOD, AND DEVICE PERFORMANCE WILL BE MEASURED IN PRE-CLINICAL LARGE-ANIMAL STUDIES. SUCCESSFUL COMPLETION OF THE PROPOSED PROJECT WILL DEMONSTRATE INTESTINAL LENGTHENING IN VIVO, ACHIEVED VIA A MINIMALLY INVASIVE PROCEDURE, AND ESTABLISH A FOUNDATION FOR PLANNING SUBSEQUENT PRECLINICAL TESTING THAT WILL BE REQUIRED FOR REGULATORY APPROVAL TO COMMERCIALIZE THE PRODUCT. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $499.9k | 9/5/25 | ||
| Not listed | $970.5k | 4/19/23 |