Project Grant 2217777
- The National Science Foundation (NSF) awarded a 5-year, $695,000 Project Grant under the Engineering program (CFDA 47.041) to Case Western Reserve University (CWRU). The grant supports research to investigate the structural implications of nucleic acid nanoparticles on their transcription, translation, and transport for delivering therapeutic drug molecules or genes to cells. Key objectives include: Encoding synthetic DNA nanoparticles with gene sequences and measuring their interaction with the...
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded Iowa State University of Science and Technology (Iowa State University) $552,075 for a project titled "Designing DNA Origami for Force-Mediated Release of Molecular Cargo". The project aims to design, build, and test a nanosized container made using DNA origami techniques that can release molecular cargo in response to small forces exerted within tissues. Key tasks include selecting extracellular matrix...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 to Nanodesk, LLC will develop a computer-aided design software platform for DNA origami nanostructures. The platform will streamline the design-build-test-learn cycle, enabling more efficient research and development of DNA origami applications in areas such as drug delivery, biosensing, materials science, and molecular computing. The project will focus on improving the...
- This National Science Foundation (NSF) Project Grant award, under the Engineering program (CFDA 47.041), provides $129,552 to the University of Tennessee to conduct collaborative research on directed assembly of nanoparticles and polymers via co-crystallization. The primary objectives are to: 1) understand the co-crystallization process of polymers and nanoparticles; 2) control the structure of nanoparticle crystalsomes formed through co-crystallization; and 3) tune nanoparticle crystalsomes...
- This Project Grant award of $300,000 from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The project aims to integrate high-level and low-level computational models to enable more powerful and user-friendly multiscale modeling frameworks for DNA nanotechnology. Key objectives include parameterizing coarse-grained...
- The National Science Foundation (NSF), through its Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), awarded a $451,093 Project Grant to the New Jersey Institute of Technology (NJIT) to investigate the interactions between flexible nanofilaments and biological cell membranes. The research aims to understand the mechanisms by which these nanofilaments adhere to and induce deformation in human and animal cells, leading to the organization and self-assembly of the...
- This Project Grant award of $316,760.00 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) aims to develop "Algorithmic Shape Encoding at the Nanoscale." The research will focus on creating mathematical tools to distinguish molecules based on their 3D shapes and structures, and then use this to construct increasingly complex self-assembling DNA-based nanostructures. Expected outcomes include breakthroughs in...
- This $450,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to understand and control the interfacial dynamics governing the formation of discrete tiles of nanoparticle assemblies on functionalized fluid interfaces. The research combines experimental and computational methods to investigate and manipulate the thermodynamic and kinetic factors influencing nanoparticle assembly at fluid interfaces. The goal is to achieve precise control...
- This $236,309 National Science Foundation project grant supports fundamental research at Virginia Polytechnic Institute and State University to develop a novel approach for harnessing three-dimensional multi-stability induced by origami folding to engineer multi-functional material systems. The one-year project beginning July 15, 2022 aims to transform the ancient art of origami into a theoretical framework for designing materials with unprecedented functions through the NSF Engineering...
- This $100,000 two-year Project Grant from the National Science Foundation's Office of Emerging Frontiers and Multidisciplinary Activities, under the Engineering (47.041) program, will support research at Boise State University to develop a co-design model integrating DNA nanotechnology and two-dimensional materials for advanced semiconductor manufacturing and workforce development. Specifically, the University will design DNA nanostructure templates for atomic precision patterning and doping...
This $455,000 three-year Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the University of Tennessee, Knoxville on the reconfigurability of deformable DNA origami nanoparticles on biomembranes. The grant objectives are to quantitatively characterize the adsorption and organization of flexible, reconfigurable DNA origami nanostructures on lipid membranes and establish how particle flexibility, membrane deformability, and resulting configurations drive self-assembly. Specific aims include assessing membrane-mediated deformations of adsorbed nanoparticles; classifying behaviors of nanoparticle populations at higher densities; and studying stimuli-triggered reconfigurability of membrane-associated nanoparticles. Outreach efforts will broaden research participation, enhance scientific knowledge, and increase college preparedness. This award supports the NSF Engineering Directorate's Engineering program (CFDA #47.041) to improve innovation and excellence in engineering research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $455.0k | 7/21/22 |