Project Grant 2213966
- This $131,910 Project Grant awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to Virginia Polytechnic Institute & State University (Virginia Tech) seeks to further the development of histotripsy, a non-thermal ablation technique, for the treatment of osteosarcoma (OS) in dogs. The project aims to: 1) investigate the treatment parameters and strategies needed for complete ablation of ex vivo canine OS tumors, and 2) test these strategies in pilot clinical...
- This $125,685 Project Grant award from the National Institutes of Health's (NIH) Office of Research Infrastructure Programs (CFDA 93.351) will support a comparative analysis of DNA damage and repair capacity in dogs to improve cancer risk prediction. The Broad Institute, Inc. will conduct this research to better understand the higher incidence of cancer and faster accumulation of somatic mutations in dogs compared to humans. The study will assess contributions from increased exposure to...
- This federal Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), aims to improve mucosal melanoma therapy by harnessing the immunogenicity of the R3LCMV virus. The $667,553 award to Northwestern University, spanning 2025-2029, has two key objectives: Determine whether neoadjuvant R3LCMV treatment improves disease-free survival in dogs with naturally occurring mucosal melanoma through a placebo-controlled veterinary...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $210,789 to Texas A&M University System Health Science Center to conduct research on a DKK-1 targeting antisense therapy for osteosarcoma. The research aims to characterize the effects of a canine version of the DKK-1 inhibiting antisense therapy (cDKKMO) on canine osteosarcoma cell lines and patient-derived xenografts, as well as test the therapy's ability to inhibit tumor...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $419,080.00 to Virginia Polytechnic Institute & State University (Virginia Tech) to evaluate a combination therapy approach using histotripsy tumor ablation and the immunostimulant n-dihydrogalactochitosan (GC) for treating osteosarcoma. The award will fund a comparative oncology study that incorporates murine preclinical models and pet dogs with spontaneous appendicular...
- Oregon State University was awarded a $1,209,960 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences on June 1, 2021, with a completion date of May 31, 2025. The grant is being used to support research under the Biological Sciences (CFDA 47.074) federal grant program. Specifically, the funding will support development of ideal eukaryotic tetrazine ligations for imaging protein dynamics in live cells. The goal is to advance scientific understanding of...
- The Department of Agriculture Animal and Plant Health Inspection Service awarded Oregon State University a $908,732 Cooperative Agreement under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025). Through this award, Oregon State University will test approximately 1,600 wild animal specimens in Oregon for the presence of SARS-CoV-2, the virus that causes COVID-19. If any samples test positive, the university will fully sequence the viral genome. The university...
- This $672,844 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research conducted by Northwestern University to target the MHC I chain-related molecule (MIC) to augment adoptive natural killer (NK) cell therapy using the canine soft tissue sarcoma model. The research aims to better understand and optimize combination therapy approaches involving anti-MIC antibodies that can modulate the tumor microenvironment to reinvigorate CD8...
- Oregon State University was awarded a $711,268 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant is part of the Biological Sciences program (CFDA 47.074) and will fund research from July 1, 2021 to June 30, 2024 exploring self versus group-sensing in bacteria. As part of the Biological Sciences program's goal to strengthen the nation's biological research enterprise and increase scientific understanding, this project aims to advance...
- The National Science Foundation (NSF) awarded a $353,843 Project Grant under CFDA Program 47.041 (Engineering) to the University of Washington to develop a unique biosensing system in E. coli bacteria to recognize extracellular cancer antigens and respond with a toxic, immunostimulatory payload. This 3-year project from March 2025 to February 2028 aims to create programmable and dynamically-responsive bacterial therapeutics as a low-cost alternative to engineered human T cell therapies for...
Oregon State University will receive $500,000 from the National Science Foundation under the Technology, Innovation, and Partnerships program to develop cancer therapeutics for dogs. Specifically, the university will construct and test prototype dual epitope-binding therapeutic antibodies targeting the canine PD-1 protein for the treatment of canine cancers. Researchers will design various single domain antibody configurations and select an optimal construct using recombinant DNA methods and yeast expression systems. Large-scale production feasibility and purification methods will be examined. The goal is to produce a robust binding prototype to provide potent therapeutic benefit for the nearly 6 million dogs diagnosed with cancer annually in a more affordable manner compared to existing human therapies. The award period is from June 15, 2022 to November 30, 2023.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $250.0k | 6/17/22 |