Daniel Brauer was awarded a $300,000 National Science Foundation Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-ASCEND) project grant to conduct research and broaden participation activities from May 1, 2022 to April 30, 2025.
Under the grant, Dr. Brauer will use the miniature protein ZF5.3 to increase understanding of endosomal escape mechanisms and shed light on structure-activity relationships during this process. The research will develop a novel time-dependent photocatalyst-based proximity labeling strategy to identify protein and lipid partners of ZF5.3 as it traverses the endocytic pathway. It will also create a high-throughput assay to establish structure-activity relationships guiding ZF5.3 escape with and without protein cargo. This may allow greater comprehension of intracellular protein therapeutics. Additionally, Dr. Brauer intends to use quantitative survey data to generate targeted solutions improving inclusion and persistence among postdoctoral scholars at the University of California, Berkeley's College of Chemistry, where the research will take place under the sponsorship of Dr. Alanna Schepartz. This award falls under the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to promote and strengthen the scientific enterprise.
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