Project Grant 2029572

This $1 million cooperative agreement from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a microbial discovery and biosynthesis platform for targeted protease inhibitors to treat COVID-19. Think Bioscience, Inc. will expand its demonstrated approach using microbial systems to guide the discovery and assembly of protease inhibitors. The company will generate new intellectual property covering the discovery platform and promising small molecules...

This SBIR Phase I award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $273,550 to Biocognon LLC for the development of a combinatorial platform to discover improved molecular recognition components for use in therapeutic and diagnostic antibodies. The project aims to utilize synthetic biology, next-generation DNA sequencing, and computational biology to efficiently generate and screen libraries of antibody...

This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...

This $1,000,000 Cooperative Agreement awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports research and development efforts by Akanocure Pharmaceuticals Inc. to optimize a novel, broad-spectrum antiviral and immunomodulatory agent for oral administration against coronaviruses. The project focuses on lead optimization, including the design, synthesis, and testing of analogs with improved drug-like properties for...

Eradivir Inc. received a $256,000 Small Business Technology Transfer (STTR) Phase I Project Grant from the National Science Foundation to develop a therapeutic molecule for COVID-19. Under the grant, awarded February 15, 2021 for the period through January 31, 2022, Eradivir will conduct research at its facilities in West Lafayette, Indiana under the NSF's Engineering program (CFDA #47.041). The Engineering program seeks to improve quality of life and economic strength through fostering...

This STTR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a new analytical toolkit for optimizing and discovering combination drug therapies. The $284,736 award, effective March 1, 2025 through February 28, 2026, will enable the awardee, Duet Biosystems, Inc., to leverage artificial intelligence (AI) to analyze laboratory and clinical data to identify the most effective drug combinations...

This SBIR Phase I award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $305,000 to Plexymer, Inc. to develop an AI-powered automation platform to accelerate the formulation of antibody therapeutics. The project aims to reduce the time and materials required to formulate antibody medicines, potentially enabling a transition from hospital infusions to self-administered at-home injections. The AI-driven platform will model and...

The U.S. National Science Foundation (NSF) awarded a $303,864 Phase I Small Business Innovation Research (SBIR) grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Core Biotherapeutics, Inc. (UEI N9FGZ15RQGJ4) located in Ladera Ranch, CA. The project aims to develop a platform for discovering therapeutic drug candidates that can modulate molecular networks driving diseases, with the potential to produce disease-modifying effects for neurodegenerative...

The National Science Foundation Division of Industrial Innovation awarded $255,700 to Creative Biotherapeutics LLC through its Engineering program (CFDA 47.041) on January 15, 2021 to fund the project "SBIR PHASE I: STRESS PATHWAY INHIBITION PREVENTS COVID-19 INFECTION (COVID-19)." This Project Grant will support Creative Biotherapeutics' research efforts through December 31, 2021 to develop inhibitors of stress response pathways to prevent COVID-19 infection. The NSF Engineering...

Phenotarget Biosciences Inc. was awarded a $255,473 Project Grant from the National Science Foundation Division of Industrial Innovation under the Engineering (47.041) federal grant program. The grant supports discovery and development of macrocyclic peptide inhibitors of SARS-CoV-2 spike protein for the treatment of COVID-19 from July 1, 2021 through March 31, 2022. The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in...