Project Grant 20236701539262
- The Department of Agriculture's National Institute of Food and Agriculture awarded a $120,000 Project Grant under the Agriculture and Food Research Initiative competitive grants program to Virginia Polytechnic Institute & State University from July 2021 through June 2023. The grant funds research to investigate embryonic losses occurring during blastocyst hatching and embryo elongation in cattle, which can significantly impact the cattle industry. The principal investigator will...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $300,000 project grant from the USDA's Institute of Food Production and Sustainability under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), effective March 1, 2026 through February 29, 2028. The award supports fundamental research into early cattle embryo development, specifically investigating the role of the maternal enzyme MOF (Males Absent On the First) and its epigenetic...
- Federal Grant Award Summary Emgenisys Inc. received a $175,000 Project Grant from the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Small Business Innovation Research (SBIR) Program (CFDA 10.212), awarded August 15, 2025, with completion targeted for April 14, 2026. The company is developing a non-invasive, artificial intelligence-based tool that uses smartphone-mounted microscope video technology to predict the sex of bovine embryos in real-time....
- Federal Grant Award Summary Membrane Protective Technologies, Inc. received a $181,500 Phase I Project Grant award from the National Institute of Food and Agriculture (NIFA) under the Small Business Innovation Research (SBIR) Program (CFDA 10.212), effective August 15, 2025, with a completion date of April 14, 2026. The award supports development of plant-based semen extenders for bull sperm cryopreservation to replace traditional animal-derived products such as egg yolk and whole milk. The...
- Federal Grant Award Summary Washington State University received a $300,000 Project Grant from the Institute of Food Production and Sustainability under the Agriculture and Food Research Initiative (AFRI) (CFDA 10.310) to conduct fundamental research on epigenetic modifications in cattle placental development. The award, obligated on February 1, 2026, with a completion date of January 31, 2028, funds the identification and characterization of parent-specific epigenetic factors that influence...
- Federal Grant Award Summary Texas A&M Agrilife Research received an $800,000 Project Grant from the USDA's Institute of Food Production and Sustainability under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), effective September 1, 2025, through August 31, 2028. The award funds research to address functional annotation of animal genomes (FAANG) by characterizing enhancer elements—regulatory DNA sequences that control gene expression—across multiple bovine...
- Federal Grant Award Summary Texas A&M Agrilife Research received a $300,000 Project Grant award from the U.S. Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), effective January 15, 2026, through January 14, 2028. The award supports development of BRDSeq, a molecular diagnostic tool designed to identify disease-causing bacteria and viruses associated with bovine respiratory disease (BRD)...
- This Cooperative Agreement award from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025) provides $197,482 to Iowa State University to develop standardized protocols for next-generation sequencing (NGS) of animal pathogens. The project aims to address the lack of consistency in NGS data analysis and reporting across veterinary diagnostic laboratories. The award will fund...
- Federal Cooperative Agreement Summary Seek Laboratories, Inc. received a $2.0 million Cooperative Agreement from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025), awarded February 2, 2026, with completion targeted for December 31, 2028. The award supports the development of a programmable CRISPR gene-editing platform designed to combat highly pathogenic avian influenza...
- Federal Grant Award Summary Purdue University received a $650,000 Project Grant from the USDA National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) Foundational and Applied Science Program (CFDA 10.310), effective February 1, 2026, through January 31, 2030. The research project investigates trophoblast Kunitz domain proteins (TKDPs) and their role in early pregnancy success in cattle. The project will employ gene knockout studies and advanced...
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROPOSAL ADDRESSES THE UNMET NEED FOR DEVELOPING HIGH THROUGHPUT PHENOTYPING FOR COLLECTING COMPREHENSIVE PHENOTYPES OF PRODUCTION, REPRODUCTION AND FITNESS TRAITS, A MAJOR EMPHASIS AREA OF THE USDA BLUEPRINT FOR ANIMAL GENOME RESEARCH 2022-2027. WE IDENTIFIED A LARGE SET OF DELETERIOUS GENE VARIANTS ASSOCIATED WITH SPECIFIC SPERM DEFECTS IN THE GENOMES OF 85 GENETICALLY VALUABLE BULLS WITH SUBOPTIMAL ARTIFICIAL INSEMINATION (AI) FERTILITY. WE NOW PROPOSE TO DEVELOP A SECOND GENERATION, LABEL-FREE SPERM PHENOTYPING PIPELINE, ELIMINATING VARIANCE AND COSTS ASSOCIATED WITH THE CONVENTIONAL, PROBE-BASED APPROACHES, BASED ON THE SPECIFIC GENOMIC DETERMINANTS OF ABERRANT SPERM QUALITY RESULTING IN UNIQUE MORPHOMETRIC AND OPTICAL PROPERTIES OF SPERMATOZOA, CAPTURED BY THE NEXT-GENERATION, BRIGHTFIELD IMAGE-BASED FLOW CYTOMETRY (IBFC) AND TRANSLATABLE TO HIGH-PRECISION PHENOTYPING OF HERITABLE PRODUCTION TRAITS. OBJECTIVE #1 IS TO PHENOTYPE AND VALIDATE RARE DELETERIOUS POLYMORPHISMS ASSOCIATED WITH ABERRANT SPERM HEAD AND TAIL MORPHOLOGIES WILL GROUP THE 85 SEQUENCED BULLS GROUPED BASED ON PREVAILING SPERM DEFECT PHENOTYPE, TO BE PHENOTYPED BY USING A MULTIPLEX PROTEOMIC APPROACH VALIDATED BY OUR PRELIMINARY DATA, OBJECTIVE #2 WILL DEVELOP A LABEL FREE SPERM PHENOTYPING PIPELINE FOR BULL FERTILITY TESTING, TRANSLATABLE TO SOMATIC CELL PHENOTYPING FOR OTHER HERITABLE TRAITS BY USING IBFC'S DEDICATED FEATUREFINDER SOFTWARE INTEGRATED WITH OUR MACHINE LEARNING PIPELINE, FOLLOWED BY VALIDATION ASSESSING SPERM STRUCTURAL INTEGRITY, GENTLE LIVE CELL SORTING AND METABOLOMICS. SUCH HIGHLY INNOVATIVE GENOME-TO-PHENOME PROJECT WILL ALIGN ANIMAL GENOMIC SELECTION WITH STATE-OF-THE-ART ANIMAL ANDROLOGY, VETERINARY DIAGNOSTICS AND PRECISION BREEDING, SUPPORTING THE IMPROVEMENT OF LIVESTOCK INDUSTRY EFFICIENCY THROUGH GLOBAL APPROACHES INTEGRATING PRODUCTION, REPRODUCTION, NUTRITION, HEALTH, AND WELFARE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 2/13/23 |