This federal Cooperative Agreement award of $558,775 from the National Cancer Institute's Cancer Cause and Prevention Research program (CFDA 93.393) aims to overcome the limitations of BET inhibition in NUT carcinoma, an aggressive form of cancer with poor outcomes. The award supports a two-pronged approach: 1) determining the mechanism by which the histone methyltransferase EZH2 cooperates with the BRD4-NUT oncoprotein to drive NUT carcinoma growth, and 2) elucidating the role of the MLL1-NUTM1 fusion protein in BRD4-NUT's oncogenic function. The award was made to Brigham & Women's Hospital Inc., a prominent academic medical center and research institution in Boston, Massachusetts. The hospital will collaborate with Dr. Kyle Eagen at Baylor College of Medicine to perform genomic and chromatin analyses necessary to accomplish the research objectives.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $558.8k | 7/30/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
131443S | Baylor College Of Medicine | Cooperative Agreement U01CA294062 | $260.0k | 11/25/24 |